Development of disease and virus recovery in transgenic mice containing HIV proviral DNA. Academic Article uri icon

Overview

abstract

  • Transgenic mice containing intact copies of the human immunodeficiency virus (HIV) proviral DNA were constructed. Founder animals were not viremic for HIV and remained healthy during a 9-month observation period. After being mated with nontransgenic animals, one founder mouse (No. 13) gave rise to F1 progeny that developed a disease syndrome characterized by marked epidermal hyperplasia, lymphadenopathy, splenomegaly, pulmonary lymphoid infiltrates, growth retardation, and death by day 25 of life. Infectious HIV, indistinguishable from parental virus by immunoblot analysis, was recovered from the spleen, lymph nodes, and skin of five of five affected animals.

publication date

  • December 23, 1988

Research

keywords

  • Acquired Immunodeficiency Syndrome
  • DNA, Viral
  • Disease Models, Animal
  • HIV

Identity

Scopus Document Identifier

  • 0024235999

Digital Object Identifier (DOI)

  • 10.1126/science.3201255

PubMed ID

  • 3201255

Additional Document Info

volume

  • 242

issue

  • 4886