MerTK Blockade Fuels Anti-tumor Immunity. uri icon

Overview

abstract

  • Phagocytosis of apoptotic cells via the receptor MerTK is important for immune tolerance. In this issue of Immunity, Zhou et al. report that blockade of MerTK-mediated phagocytosis mobilizes anti-tumor immunity through a mechanism that involves the transport of tumor-derived cGAMP into macrophages via the ATP-activated channel P2X7R.

publication date

  • February 18, 2020

Research

keywords

  • Apoptosis
  • Macrophages

Identity

Scopus Document Identifier

  • 85079167737

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2020.01.015

PubMed ID

  • 32075723

Additional Document Info

volume

  • 52

issue

  • 2