Autophagy in chronic lung disease. uri icon

Overview

abstract

  • The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory and protective/barrier functions necessary to manage the chronic exposures to environmental, mechanical, and oxidative stressors. Autophagy is essential to lung development and homeostasis, as well as the prevention and development of disease. The cellular process involves the collection and removal of unwanted organelles and proteins through lysosomal degradation. In recent years, investigations have addressed the roles of autophagy and selective autophagy in numerous chronic lung diseases. Here, we highlight recent advances on the role of autophagy in the pathogenesis of asthma, chronic obstructive pulmonary disease and emphysema, pulmonary arterial hypertension, and idiopathic pulmonary fibrosis.

publication date

  • March 12, 2020

Research

keywords

  • Autophagy
  • Lung Diseases

Identity

PubMed Central ID

  • PMC8608369

Scopus Document Identifier

  • 85081939211

Digital Object Identifier (DOI)

  • 10.1016/bs.pmbts.2020.02.001

PubMed ID

  • 32620240

Additional Document Info

volume

  • 172