An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis. Academic Article uri icon

Overview

abstract

  • This protocol provides the steps required for a mouse liver orthotopic implantation model. The reliable pre-clinical animal models that have similar characteristics to hepatocellular carcinoma (HCC) are a powerful tool to unveil the mechanisms controlling tumor initiation and progression. Here, we describe a syngeneic orthotopic HCC model that recapitulates the role of a host pro-tumorigenic microenvironment by pre-conditioning mouse livers with a high-fat diet (HFD). For complete details on the use and execution of this protocol, please refer to Kudo et al. (2020).

publication date

  • November 20, 2020

Research

keywords

  • Carcinoma, Hepatocellular
  • Fatty Liver
  • Liver Neoplasms

Identity

PubMed Central ID

  • PMC7757567

Scopus Document Identifier

  • 85108265232

Digital Object Identifier (DOI)

  • 10.1016/j.xpro.2020.100185

PubMed ID

  • 33377079

Additional Document Info

volume

  • 1

issue

  • 3