Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice. Academic Article uri icon

Overview

abstract

  • Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan benefits. Selenium supplementation inhibits IGF-1 signaling in rats and has been studied for its putative healthspan benefits. Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Selenomethionine supplementation results in a similar, albeit less robust response, and also extends budding yeast lifespan. Our results indicate that selenium supplementation is sufficient to produce MR-like healthspan benefits for yeast and mammals.

publication date

  • March 30, 2021

Research

keywords

  • Insulin-Like Growth Factor I
  • Methionine
  • Mice
  • Selenium
  • Selenomethionine
  • Sodium Selenite

Identity

PubMed Central ID

  • PMC8009673

Scopus Document Identifier

  • 85103334153

Digital Object Identifier (DOI)

  • 10.1126/sciadv.aba1306

PubMed ID

  • 33783357

Additional Document Info

volume

  • 10