Tyler, Jessica

Publications

Sort by

Co-Author Network

selected publications

Editorial: Germ cell development and reproductive aging. Frontiers in cell and developmental biology. 2022 Editorial Article GET IT
Times cited: 3058
A Simple, Improved Method for Scarless Genome Editing of Budding Yeast Using CRISPR-Cas9. Methods and protocols. 2022 Academic Article GET IT
Times cited: 3098
The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways. Frontiers in cell and developmental biology. 2022 Review GET IT
Times cited: 466
A Flow Cytometry-Based Method for Analyzing DNA End Resection in G₀- and G₁-Phase Mammalian Cells. Bio-protocol. 2022 Academic Article GET IT
DNA-PK promotes DNA end resection at DNA double strand breaks in G₀ cells. eLife. 2022 Academic Article GET IT
Times cited: 2
Reprogramming Carbohydrate Metabolism in Cancer and Its Role in Regulating the Tumor Microenvironment. Sub-cellular biochemistry. 2022 Academic Article GET IT
Times cited: 1
A Proximity Ligation Method to Detect Proteins Bound to Single-Stranded DNA after DNA End Resection at DNA Double-Strand Breaks. Methods and protocols. 2021 Academic Article GET IT
Times cited: 997
Chaperoning histones at the DNA repair dance. DNA repair. 2021 Review GET IT
Times cited: 5
LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. eLife. 2021 Academic Article GET IT
Times cited: 8
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining. DNA repair. 2021 Academic Article GET IT
Times cited: 7
Histone and Chromatin Dynamics Facilitating DNA repair. DNA repair. 2021 Academic Article GET IT
Times cited: 3
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 3
Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice. eLife. 2021 Academic Article GET IT
Times cited: 13
A new era for research into aging. eLife. 2021 Editorial Article GET IT
Times cited: 1
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. Molecular cell. 2020 Article GET IT
Times cited: 2
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer cell. 2019 Academic Article GET IT
Times cited: 44
XLF and H2AX function in series to promote replication fork stability. The Journal of cell biology. 2019 Academic Article GET IT
Times cited: 13
Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?. Current genetics. 2019 Review GET IT
Times cited: 12
Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan. eLife. 2018 Academic Article GET IT
Times cited: 41
The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks. Cell cycle (Georgetown, Tex.). 2018 Academic Article GET IT
Times cited: 5
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Molecular cell. 2018 Academic Article GET IT
Times cited: 60
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. Molecular cell. 2018 Academic Article GET IT
Times cited: 51
Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks. FEBS open bio. 2018 Academic Article GET IT
Times cited: 7
Impaired cohesion and homologous recombination during replicative aging in budding yeast. Science advances. 2018 Academic Article GET IT
Times cited: 25
The role of autophagy in the regulation of yeast life span. Annals of the New York Academy of Sciences. 2018 Review GET IT
Times cited: 26
Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break. Nucleic acids research. 2017 Academic Article GET IT
Times cited: 10
The integrated stress response in budding yeast lifespan extension. Microbial cell (Graz, Austria). 2017 Review GET IT
Times cited: 469
Anchoring Chromatin Loops to Cancer. Developmental cell. 2017 Comment GET IT
Times cited: 2
Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast. PloS one. 2017 Academic Article GET IT
Times cited: 12
Thinking Outside the Cell: Replicating Replication In Vitro. Molecular cell. 2017 Academic Article GET IT
Times cited: 1
Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes. Cell cycle (Georgetown, Tex.). 2016 Academic Article GET IT
Times cited: 29
The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. eLife. 2016 Academic Article GET IT
Times cited: 63
Nucleosomes Find Their Place in Life. Trends in genetics : TIG. 2016 Comment GET IT
Times cited: 3
Epigenetics and aging. Science advances. 2016 Review GET IT
Times cited: 439
Physiology: Stressed-out chromatin promotes longevity. Nature. 2016 Academic Article GET IT
Times cited: 1
Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly. eLife. 2016 Academic Article GET IT
Times cited: 49
Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans. Cell cycle (Georgetown, Tex.). 2016 Academic Article GET IT
Times cited: 1
The Commercial Antibodies Widely Used to Measure H3 K56 Acetylation Are Non-Specific in Human and Drosophila Cells. PloS one. 2016 Academic Article GET IT
Times cited: 9
TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Science advances. 2016 Academic Article GET IT
Times cited: 26
Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila. Epigenetics & chromatin. 2016 Academic Article GET IT
Times cited: 18
Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. eLife. 2016 Academic Article GET IT
Times cited: 20
The Overlooked Fact: Fundamental Need for Spike-In Control for Virtually All Genome-Wide Analyses. Molecular and cellular biology. 2015 Academic Article GET IT
Times cited: 101
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics & chromatin. 2015 Academic Article GET IT
Times cited: 119
HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. Oncotarget. 2015 Academic Article GET IT
Times cited: 33
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell reports. 2014 Academic Article GET IT
Times cited: 30
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice. Cell reports. 2014 Academic Article GET IT
Times cited: 53
Transcriptional and genomic mayhem due to aging-induced nucleosome loss in budding yeast. Microbial cell (Graz, Austria). 2014 Comment GET IT
Times cited: 2
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 46
Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. Genes & development. 2014 Academic Article GET IT
Times cited: 207
A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators. Transcription. 2014 Academic Article GET IT
Times cited: 2
Mitotic phosphorylation of histone H3 threonine 80. Cell cycle (Georgetown, Tex.). 2013 Academic Article GET IT
Times cited: 28
How is epigenetic information maintained through DNA replication?. Epigenetics & chromatin. 2013 Academic Article GET IT
Times cited: 48
At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence. Frontiers in genetics. 2013 Academic Article GET IT
Times cited: 552
Histone exchange and histone modifications during transcription and aging. Biochimica et biophysica acta. 2013 Review GET IT
Times cited: 73
DANPOS: dynamic analysis of nucleosome position and occupancy by sequencing. Genome research. 2012 Academic Article GET IT
Times cited: 234
The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4. Molecular and cellular biology. 2012 Academic Article GET IT
Times cited: 17
The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability. Epigenetics & chromatin. 2012 Academic Article GET IT
Times cited: 302
Epigenetic regulation of genomic integrity. Chromosoma. 2012 Review GET IT
Times cited: 36
Chromatin structure as a mediator of aging. FEBS letters. 2010 Review GET IT
Times cited: 145
Elevated histone expression promotes life span extension. Molecular cell. 2010 Academic Article GET IT
Times cited: 304
The histone shuffle: histone chaperones in an energetic dance. Trends in biochemical sciences. 2010 Review GET IT
Times cited: 140
Chaperoning histones during DNA replication and repair. Cell. 2010 Review GET IT
Times cited: 254
Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. Cell cycle (Georgetown, Tex.). 2009 Comment GET IT
Times cited: 1
Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators. Epigenetics & chromatin. 2009 Academic Article GET IT
Times cited: 45
FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 53
CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature. 2009 Academic Article GET IT
Times cited: 566
Chromatin reassembly signals the end of DNA repair. Cell cycle (Georgetown, Tex.). 2008 Review GET IT
Times cited: 26
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell. 2008 Academic Article GET IT
Times cited: 327
Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 174
Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators. Molecular and cellular biology. 2007 Academic Article GET IT
Times cited: 73
Transcriptional regulation by chromatin disassembly and reassembly. Current opinion in genetics & development. 2007 Review GET IT
Times cited: 69
Chromatin disassembly and reassembly during DNA repair. Mutation research. 2007 Review GET IT
Times cited: 31
The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 75
Structural basis for the histone chaperone activity of Asf1. Cell. 2006 Academic Article GET IT
Times cited: 351
Global replication-independent histone H4 exchange in budding yeast. Eukaryotic cell. 2006 Academic Article GET IT
Times cited: 19
Dominant mutants of the Saccharomyces cerevisiae ASF1 histone chaperone bypass the need for CAF-1 in transcriptional silencing by altering histone and Sir protein recruitment. Genetics. 2006 Academic Article GET IT
Times cited: 19
Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions. Molecular cell. 2006 Academic Article GET IT
Times cited: 139
The histone chaperone ASF1 localizes to active DNA replication forks to mediate efficient DNA replication. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Academic Article GET IT
Times cited: 64
ASF1 binds to a heterodimer of histones H3 and H4: a two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA. Biochemistry. 2005 Academic Article GET IT
Times cited: 109
The yeast histone chaperone chromatin assembly factor 1 protects against double-strand DNA-damaging agents. Genetics. 2005 Academic Article GET IT
Times cited: 61
Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones. Eukaryotic cell. 2005 Academic Article GET IT
Times cited: 33
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 247
Heterochromatin focuses on senescence. Molecular cell. 2005 Academic Article GET IT
Times cited: 13
The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 45
Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 83
The histone chaperone Asf1p mediates global chromatin disassembly in vivo. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 92
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes. Molecular cell. 2004 Academic Article GET IT
Times cited: 256
Chromatin assembly. Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines. European journal of biochemistry. 2002 Review GET IT
Times cited: 123
Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Molecular and cellular biology. 2001 Academic Article GET IT
Times cited: 177
The RCAF complex mediates chromatin assembly during DNA replication and repair. Nature. 1999 Academic Article GET IT
Times cited: 449
The "dark side" of chromatin remodeling: repressive effects on transcription. Cell. 1999 Review GET IT
Times cited: 206
Chromatin assembly factors: a dual function in nucleosome formation and mobilization?. Genes to cells : devoted to molecular & cellular mechanisms. 1997 Review GET IT
Times cited: 65
Replacement of the herpes simplex virus type 1 Vmw175 DNA binding domain with its varicella-zoster virus counterpart results in a protein with novel regulatory properties that can support virus growth. The Journal of general virology. 1997 Academic Article GET IT
The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 119
ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 86
The DNA binding domains of the varicella-zoster virus gene 62 and herpes simplex virus type 1 ICP4 transactivator proteins heterodimerize and bind to DNA. Nucleic acids research. 1994 Academic Article GET IT
Times cited: 19
Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein. Nucleic acids research. 1994 Academic Article GET IT
Times cited: 23
An epitope within the DNA-binding domain of the herpes simplex virus immediate early protein Vmw175 is conserved in the varicella-zoster virus gene 62 protein. The Journal of general virology. 1993 Academic Article GET IT
Times cited: 15
The DNA binding domain of the varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1. Nucleic acids research. 1993 Academic Article GET IT
Times cited: 33

more ...

less ...

Research

Sort by

Co-investigator Network

Funding awarded

Novel pathways that regulate DNA double-strand break repair events in mammalian cells awarded by National Institute of General Medical Sciences Principal Investigator 2021 - 2026
2nd Biennial ASBMB - BSC Symposium on the Interplay between Epigenetic Regulation and Genome Integrity awarded by National Institute on Aging Principal Investigator 2022 - 2023
Addgene 704163 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Chromatin''s Role in Repair of Radiation-induced Damage awarded by National Cancer Institute Principal Investigator 2018 - 2023

High-resolution genomic mapping of ssDNA binding proteins for Alzheimer''s disease research awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2022 - 2023

more ...

less ...

Background

education and training

Ph.D., University of Glasgow (United Kingdom) 1994
B.S., University of Sheffield (United Kingdom) 1990

Contact

full name

Jessica Tyler

primary email

jet2021@med.cornell.edu

VIVO Weill Cornell Medical College

Jessica Tyler Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email