Cell and Tissue Therapy for the Treatment of Chronic Liver Disease. Review uri icon

Overview

abstract

  • Liver disease is an important clinical problem, impacting 600 million people worldwide. It is the 11th-leading cause of death in the world. Despite constant improvement in treatment and diagnostics, the aging population and accumulated risk factors led to increased morbidity due to nonalcoholic fatty liver disease and steatohepatitis. Liver transplantation, first established in the 1960s, is the second-most-common solid organ transplantation and is the gold standard for the treatment of liver failure. However, less than 10% of the global need for liver transplantation is met at the current rates of transplantation due to the paucity of available organs. Cell- and tissue-based therapies present an alternative to organ transplantation. This review surveys the approaches and tools that have been developed, discusses the distinctive challenges that exist for cell- and tissue-based therapies, and examines the future directions of regenerative therapies for the treatment of liver disease.

publication date

  • May 11, 2021

Research

keywords

  • Liver Transplantation
  • Non-alcoholic Fatty Liver Disease

Identity

PubMed Central ID

  • PMC8864721

Scopus Document Identifier

  • 85110442612

Digital Object Identifier (DOI)

  • 10.1146/annurev-bioeng-112619-044026

PubMed ID

  • 33974812

Additional Document Info

volume

  • 23