Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Academic Article uri icon

Overview

abstract

  • Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.

authors

publication date

  • November 24, 2021

Research

keywords

  • Biomarkers, Tumor
  • Colorectal Neoplasms
  • Liver Neoplasms
  • Lung Neoplasms
  • Peritoneal Neoplasms

Identity

PubMed Central ID

  • PMC8613248

Scopus Document Identifier

  • 85119827712

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2018.03.035

PubMed ID

  • 34819518

Additional Document Info

volume

  • 12

issue

  • 1