Advances in understanding and examining lymphatic function: relevance for understanding autoimmunity. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: The aim of this review is to give insights into how novel lymphatics functions may influence autoimmunity. RECENT FINDINGS: The lymphatic system connects peripheral tissues to draining lymph nodes to regulate adaptive immunity and directly interfaces with leukocytes in lymph vessels and in the lymph node. Here, we discuss recent findings showing evidence of dysfunctional lymphatics in autoimmune disease, new understanding of how afferent lymphatic regulation can modulate immunity, lymph node lymphatic heterogeneity and how these lymphatics can directly modulate lymphocyte function, how this understanding can be harnessed for new therapeutics, and new tools for the investigation of lymphatic and immune biology. SUMMARY: Lymphatics have an active role in the regulation of inflammation and the adaptive immune response. Here, we review recent findings in lymphatics biology in peripheral tissues and lymph nodes and emphasize the relevance for better understanding autoimmune diseases.

publication date

  • March 1, 2022

Research

keywords

  • Autoimmune Diseases
  • Lymphatic Vessels

Identity

Scopus Document Identifier

  • 85123901093

Digital Object Identifier (DOI)

  • 10.1097/BOR.0000000000000864

PubMed ID

  • 34954700

Additional Document Info

volume

  • 34

issue

  • 2