Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective. Review uri icon

Overview

abstract

  • A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboranes, and BODIPY, for the treatment of different human diseases.In addition, we also describe the synthesis, key structure-activity relationship, and associated biological activities, such as antimicrobial, antituberculosis, antitumor, antiparasitic, antiprotozoal, anti-inflammatory, antifolate, antidepressant, antiallergic, anesthetic, and anti-Alzheimer's agents, as well as proteasome and lipogenic inhibitors. This compilation could be very useful in the exploration of novel boron-derived compounds against different diseases, with promising efficacy and lesser side effects.

publication date

  • April 19, 2022

Research

keywords

  • Boranes
  • Boron

Identity

PubMed Central ID

  • PMC9104566

Scopus Document Identifier

  • 85129337216

Digital Object Identifier (DOI)

  • 10.1517/13543776.2014.881472

PubMed ID

  • 35565972

Additional Document Info

volume

  • 27

issue

  • 9