Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Academic Article uri icon

Overview

abstract

  • The int-1 proto-oncogene is transcriptionally activated in mammary tumors by mouse mammary tumor virus insertion mutations and is normally expressed only in adult mouse testes and mid-gestational embryos. We have used anatomical dissection of embryos, germ-cell fractionation, peripuberal expression studies, and spermatogenesis mutants to identify more precisely the tissues and cells that contain int-1 RNA. In the testis, int-1 RNA is detected only in postmeiotic germ cells undergoing differentiation from round spermatids into mature spermatozoa. In embryos 11-15 days after conception, expression of the gene is restricted to the developing central nervous system in regions of the neural tube other than the telencephalon. Our findings suggest that int-1 mediates developmental events at these two sites.

publication date

  • July 3, 1987

Research

keywords

  • Central Nervous System
  • Mice
  • Proto-Oncogenes
  • Spermatids

Identity

Scopus Document Identifier

  • 0023623377

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(87)90665-9

PubMed ID

  • 3594566

Additional Document Info

volume

  • 50

issue

  • 1