Varmus, Harold E.

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LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer discovery. 2023 Academic Article GET IT
Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell reports. 2022 Academic Article GET IT
Times cited: 9
New York's Polyethnic-1000: a regional initiative to understand how diverse ancestries influence the risk, progression, and treatment of cancers. Trends in cancer. 2021 Academic Article GET IT
Times cited: 2
The United States needs a department of technology and science policy. Nature. 2021 Article GET IT
Create a COVID-19 commission. Science (New York, N.Y.). 2021 Academic Article GET IT
Times cited: 2
Concrete steps to diversify the scientific workforce. Science (New York, N.Y.). 2021 Academic Article GET IT
Times cited: 21
Chinese scientists and US leadership in the life sciences. Nature biotechnology. 2019 Letter GET IT
Of oncogenes and open science: an interview with Harold Varmus. Disease models & mechanisms. 2019 Article GET IT
Times cited: 2
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 51
Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. eLife. 2018 Academic Article GET IT
Times cited: 46
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 46
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 35
Improving support for young biomedical scientists. Science (New York, N.Y.). 2018 Academic Article GET IT
Times cited: 6
Insurance for broad genomic tests in oncology. Science (New York, N.Y.). 2017 Academic Article GET IT
Times cited: 20
A Prize for Cancer Prevention. Cell. 2017 Academic Article GET IT
A Prize for Cancer Prevention. Cell. 2017 Academic Article GET IT
Times cited: 3
How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?. Cold Spring Harbor symposia on quantitative biology. 2017 Review GET IT
Times cited: 11
Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival. PLoS genetics. 2016 Academic Article GET IT
Times cited: 67
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 120
Toward a Shared Vision for Cancer Genomic Data. The New England journal of medicine. 2016 Academic Article GET IT
Times cited: 851
The transformation of oncology. Science (New York, N.Y.). 2016 Editorial Article GET IT
Times cited: 6
Varmus Returns to His Roots in Cancer Genetics. JAMA. 2015 Article GET IT
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. eLife. 2015 Academic Article GET IT
Times cited: 104
Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. Cancer discovery. 2015 Academic Article GET IT
Times cited: 46
Opinion: Addressing systemic problems in the biomedical research enterprise. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 41
A new initiative on precision medicine. The New England journal of medicine. 2015 Academic Article GET IT
Times cited: 3357
ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. Cancer research. 2015 Academic Article GET IT
Times cited: 24
National Cancer Institute-supported clinical trials networks. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2014 Letter GET IT
Times cited: 5
Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 500
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. Cancer discovery. 2014 Academic Article GET IT
Times cited: 154
DOK2 inhibits EGFR-mutated lung adenocarcinoma. PloS one. 2013 Academic Article GET IT
Times cited: 12
Addressing the growing international challenge of cancer: a multinational perspective. Science translational medicine. 2013 Academic Article GET IT
Times cited: 35
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 290
Three decades of Wnts: a personal perspective on how a scientific field developed. The EMBO journal. 2012 Review GET IT
Times cited: 311
A conversation with Harold Varmus. Interview by Ushma S. Neill. The Journal of clinical investigation. 2012 Article GET IT
Times cited: 1
Science funding: Provocative questions in cancer research. Nature. 2012 Academic Article GET IT
Times cited: 24
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 54
Epstein-Barr virus: an important vaccine target for cancer prevention. Science translational medicine. 2011 Academic Article GET IT
Times cited: 267
Integrating cancer control into global health. Science translational medicine. 2011 Review GET IT
Times cited: 25
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 43
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 99
Accelerating progress on non-communicable diseases. Lancet (London, England). 2011 Academic Article GET IT
Times cited: 26
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer cell. 2011 Academic Article GET IT
Times cited: 139
Newsmaker interview: Harold Varmus. Piloting cancer research with a shrinking budget. Interview by Jocelyn Kaiser. Science (New York, N.Y.). 2011 Article GET IT
Times cited: 1
NIH cancer chief wants more with less: by Meredith Wadman. Nature. 2011 Article GET IT
Times cited: 1
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature genetics. 2010 Academic Article GET IT
Times cited: 565
Ten years on--the human genome and medicine. The New England journal of medicine. 2010 Editorial Article GET IT
Times cited: 66
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma. Disease models & mechanisms. 2009 Academic Article GET IT
Times cited: 65
Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells. Journal of biomolecular screening. 2009 Academic Article GET IT
Times cited: 25
Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors. PloS one. 2009 Academic Article GET IT
Times cited: 12
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes & development. 2009 Academic Article GET IT
Times cited: 50
The enlightenment returns. Science (New York, N.Y.). 2009 Editorial Article GET IT
Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. Journal of virology. 2009 Academic Article GET IT
Times cited: 1
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene. 2009 Academic Article GET IT
Times cited: 94
Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008 Academic Article GET IT
Times cited: 2208
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 97
The 20th Aspen Cancer Conference: Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention, and Cancer Therapy 2005. Molecular carcinogenesis. 2008 Conference Paper GET IT
Times cited: 1
Seeding and propagation of untransformed mouse mammary cells in the lung. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 250
The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973. Clinical orthopaedics and related research. 2008 Review GET IT
Harold Varmus. Interview by Errol C. Friedberg. Nature reviews. Molecular cell biology. 2008 Article GET IT
NIH funds support more than a researcher's own lab. Nature. 2008 Letter GET IT
Progress toward public access to science. PLoS biology. 2008 Editorial Article GET IT
Times cited: 5
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 101
Characterizing the cancer genome in lung adenocarcinoma. Nature. 2007 Academic Article GET IT
Times cited: 933
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. PLoS biology. 2007 Academic Article GET IT
Times cited: 63
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. PloS one. 2007 Academic Article GET IT
Times cited: 80
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 85
The new era in cancer research. Science (New York, N.Y.). 2006 Academic Article GET IT
Times cited: 267
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes & development. 2006 Academic Article GET IT
Times cited: 388
Re-aim blame for NIH's hard times. Science (New York, N.Y.). 2006 Editorial Article GET IT
Times cited: 9
Support for the Human Cancer Genome Project. Science (New York, N.Y.). 2005 Letter GET IT
Times cited: 10
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome biology. 2005 Academic Article GET IT
Times cited: 42
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 504
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. 2005 GET IT
Times cited: 3130
The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 101
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS medicine. 2005 Academic Article GET IT
Times cited: 1383
Oncogenes come of age. Cold Spring Harbor symposia on quantitative biology. 2005 Review GET IT
Times cited: 22
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. The EMBO journal. 2004 Academic Article GET IT
Times cited: 269
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development (Cambridge, England). 2004 Academic Article GET IT
Times cited: 281
The knockout mouse project. Nature genetics. 2004 Academic Article GET IT
Times cited: 511
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 3911
Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC medicine. 2004 Academic Article GET IT
Times cited: 46
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 128
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 162
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes & development. 2003 Academic Article GET IT
Times cited: 100
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 456
Requirement for a nuclear function of beta-catenin in Wnt signaling. Molecular and cellular biology. 2003 Academic Article GET IT
Times cited: 63
Public health. Grand Challenges in Global Health. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 207
Why PLoS became a publisher. PLoS biology. 2003 Academic Article GET IT
Times cited: 49
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. BMC molecular biology. 2003 Academic Article GET IT
Times cited: 69
Genomic empowerment: the importance of public databases. Nature genetics. 2003 Academic Article GET IT
Times cited: 10
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 48
Medicine. The need for a global HIV vaccine enterprise. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 175
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC cell biology. 2003 Academic Article GET IT
Times cited: 113
Statement on scientific publication and security. Science (New York, N.Y.). 2003 Editorial Article GET IT
Times cited: 50
Statement on the consideration of biodefence and biosecurity. Nature. 2003 Editorial Article GET IT
Times cited: 34
Uncensored exchange of scientific results. Proceedings of the National Academy of Sciences of the United States of America. 2003 Editorial Article GET IT
Times cited: 37
Overview of the Alliance for Cellular Signaling. Nature. 2002 Academic Article GET IT
Times cited: 116
Building a global culture of science. Lancet (London, England). 2002 Academic Article GET IT
Times cited: 9
Getting ready for gene-based medicine. The New England journal of medicine. 2002 Editorial Article GET IT
Times cited: 77
Public-access group supports PubMed Central. Nature. 2002 Letter GET IT
Times cited: 4
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer cell. 2002 Academic Article GET IT
Times cited: 302
The weaknesses of science for profit. The oncologist. 2002 Editorial Article GET IT
Times cited: 1
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes & development. 2001 Academic Article GET IT
Times cited: 514
How popular TV shows shape public perceptions of medical scientists. The Mount Sinai journal of medicine, New York. 2001 Conference Paper GET IT
Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector. Journal of virology. 2001 Academic Article GET IT
Times cited: 64
Forum for agricultural biotechnology debates. Science (New York, N.Y.). 2001 Letter GET IT
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC immunology. 2001 Academic Article GET IT
Times cited: 36
A mover in the biomedical community. An interview with Harold Varmus, President of Memorial Sloan-Kettering Cancer Center in New York City and former Director of NIH by Holger Breithaupt. EMBO reports. 2001 Article GET IT
Information access. Building a "GenBank" of the published literature. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 37
Public health. Proliferation of National Institutes of Health. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 8
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC molecular biology. 2001 Academic Article GET IT
Times cited: 137
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes & development. 2001 Academic Article GET IT
Times cited: 98
Harold Varmus [interview by Karen Birmingham]. Nature medicine. 2001 Article GET IT
Times cited: 1
A comparative evaluation of beta-catenin and plakoglobin signaling activity. Oncogene. 2000 Academic Article GET IT
Times cited: 54
The National Institutes of Health and clinical research: a progress report. Nature medicine. 2000 Academic Article GET IT
Times cited: 47
Fourteenth Aspen Cancer Conference: mechanisms of toxicity, carcinogenesis and cancer prevention. Molecular carcinogenesis. 2000 Conference Paper GET IT
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene. 2000 Review GET IT
Times cited: 203
The challenge of making laws on the shifting terrain of science. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics. 2000 Conference Paper GET IT
Times cited: 3
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Molecular biology of the cell. 1999 Academic Article GET IT
Times cited: 43
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular cell. 1999 Academic Article GET IT
Times cited: 314
Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene. 1999 Review GET IT
Times cited: 137
View from the top of a biomedical empire. Interview by Eliot Marshall. Science (New York, N.Y.). 1999 Article GET IT
Evaluating the burden of disease and spending the research dollars of the National Institutes of Health. The New England journal of medicine. 1999 Editorial Article GET IT
Times cited: 37
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (New York, N.Y.). 1999 Academic Article GET IT
Times cited: 332
A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer research. 1999 Academic Article GET IT
Times cited: 133
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Molecular and cellular biology. 1999 Academic Article GET IT
Times cited: 71
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes & development. 1998 Academic Article GET IT
Times cited: 443
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. Genes & development. 1998 Academic Article GET IT
Times cited: 101
National Institutes of Health in the tropics. The American journal of tropical medicine and hygiene. 1998 Conference Paper GET IT
Times cited: 2
Science and the control of AIDS. Science (New York, N.Y.). 1998 Editorial Article GET IT
Times cited: 3
Revitalization of the Warren G. Magnuson Clinical Center at the National Institutes of Health. Academic medicine : journal of the Association of American Medical Colleges. 1998 Academic Article GET IT
Times cited: 5
Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus. Journal of virology. 1998 Academic Article GET IT
Times cited: 41
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 250
Health care reform and public health: a paper on population-based core functions. The Core Functions Project, U.S. Public Health Service, 1993. Journal of public health policy. 1998 Academic Article GET IT
Times cited: 4
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 261
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes & development. 1997 Academic Article GET IT
Times cited: 249
Ethical complexities of conducting research in developing countries. The New England journal of medicine. 1997 Academic Article GET IT
Times cited: 300
Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1997 Academic Article GET IT
Times cited: 51
US support for malaria research. Nature. 1997 Letter GET IT
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 366
Casein kinase 2 associates with and phosphorylates dishevelled. The EMBO journal. 1997 Academic Article GET IT
Times cited: 203
The spirit of Dakar: a call for action on malaria. Nature. 1997 Letter GET IT
Times cited: 17
A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science (New York, N.Y.). 1997 Academic Article GET IT
Times cited: 420
AIDS: the process of discovery. Science (New York, N.Y.). 1997 Letter GET IT
A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA. Journal of molecular biology. 1996 Academic Article GET IT
Times cited: 84
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 157
Planning of US AIDS research. Nature. 1996 Letter GET IT
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes & development. 1996 Academic Article GET IT
Times cited: 115
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Academic Article GET IT
Times cited: 101
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. Journal of virology. 1996 Academic Article GET IT
Times cited: 190
The Pastorian: a legacy of Louis Pasteur. Advances in cancer research. 1996 Academic Article GET IT
Times cited: 4
The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Progress in clinical and biological research. 1996 Review GET IT
Times cited: 22
Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation. Oncogene. 1995 Academic Article GET IT
Times cited: 41
Shattuck Lecture--biomedical research enters the steady state. The New England journal of medicine. 1995 Academic Article GET IT
Times cited: 30
A genetic screen identifies cellular factors involved in retroviral -1 frameshifting. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 32
An active National Institute of Mental Health. Science (New York, N.Y.). 1995 Letter GET IT
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes & development. 1995 Academic Article GET IT
Times cited: 296
Harold E. Varmus, MD. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 1995 Article GET IT
An overview of the FY-1996 budget for the National Institutes of Health. Academic medicine : journal of the Association of American Medical Colleges. 1995 Academic Article GET IT
Times cited: 1
Mutations associated with familial melanoma impair p16INK4 function. Nature genetics. 1995 Letter GET IT
Times cited: 256
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature. 1995 Academic Article GET IT
Times cited: 449
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes & development. 1995 Academic Article GET IT
Times cited: 247
NIH review of gene therapy protocols. Science (New York, N.Y.). 1995 Letter GET IT
Times cited: 5
Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 44
Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting. The EMBO journal. 1995 Academic Article GET IT
Times cited: 109
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation. Oncogene. 1995 Academic Article GET IT
Times cited: 5
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 114
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. The EMBO journal. 1994 Academic Article GET IT
Times cited: 223
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. The EMBO journal. 1994 Academic Article GET IT
Times cited: 183
Embryo research guidelines. Science (New York, N.Y.). 1994 Letter GET IT
The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein. Journal of virology. 1994 Academic Article GET IT
Times cited: 49
NIH R&D priorities. Science (New York, N.Y.). 1994 Letter GET IT
Basic science and the NIH. Molecular biology of the cell. 1994 Academic Article GET IT
Times cited: 3
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes & development. 1994 Academic Article GET IT
Times cited: 196
Cancer genes and hematopoiesis. Blood. 1994 Review GET IT
Times cited: 27
Defining the steps in a multistep mouse model for mammary carcinogenesis. Cold Spring Harbor symposia on quantitative biology. 1994 Review GET IT
Times cited: 4
Harold Varmus, director, National Institutes of Health. Interview by Richard Horton. Lancet (London, England). 1994 Article GET IT
Times cited: 1
Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles. Oncogene. 1994 Academic Article GET IT
Times cited: 9
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 108
Varmus: the view from Bethesda. Interview by Eliot Marshall. Science (New York, N.Y.). 1993 Article GET IT
Times cited: 2
Activity of Wnt-1 as a transmembrane protein. Genes & development. 1993 Academic Article GET IT
Times cited: 44
The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells. Neuron. 1993 Academic Article GET IT
Times cited: 49
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. Cell. 1993 Academic Article GET IT
Times cited: 311
Two wnt genes in Caenorhabditis elegans. Oncogene. 1993 Academic Article GET IT
Times cited: 28
Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses. Journal of virology. 1993 Academic Article GET IT
Times cited: 173
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 187
Science and the new administration. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 10
Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 131
Retroviral integration machinery as a probe for DNA structure and associated proteins. Cold Spring Harbor symposia on quantitative biology. 1993 Academic Article GET IT
Times cited: 8
Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro. Journal of virology. 1992 Academic Article GET IT
Times cited: 77
Simian virus 40 minichromosomes as targets for retroviral integration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 68
Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo. Journal of virology. 1992 Academic Article GET IT
Times cited: 129
Association of p60c-src with endosomal membranes in mammalian fibroblasts. The Journal of cell biology. 1992 Academic Article GET IT
Times cited: 204
Wnt genes. Cell. 1992 Review GET IT
Times cited: 834
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell. 1992 Academic Article GET IT
Times cited: 235
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Molecular biology of the cell. 1992 Academic Article GET IT
Times cited: 95
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. Journal of virology. 1992 Academic Article GET IT
Times cited: 104
Interaction of Wnt-1 proteins with the binding protein BiP. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 39
Oncogenes and cell proliferation. Current opinion in genetics & development. 1992 Article GET IT
An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 142
Retroviral integration into minichromosomes in vitro. The EMBO journal. 1992 Academic Article GET IT
Times cited: 128
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 136
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 112
Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. Journal of virology. 1991 Article GET IT
The crucial link between laboratory animal research and human health. Academic medicine : journal of the Association of American Medical Colleges. 1991 Academic Article GET IT
Times cited: 2
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host. Journal of virology. 1991 Academic Article GET IT
Times cited: 58
A new nomenclature for int-1 and related genes: the Wnt gene family. Cell. 1991 Letter GET IT
Times cited: 263
Production of p60c-src by baculovirus expression and immunoaffinity purification. Methods in enzymology. 1991 Academic Article GET IT
Times cited: 23
Efficient incorporation of human CD4 protein into avian leukosis virus particles. Science (New York, N.Y.). 1990 Academic Article GET IT
Times cited: 77
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src. Genes & development. 1990 Academic Article GET IT
Times cited: 17
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. Journal of virology. 1990 Academic Article GET IT
Times cited: 100
Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. Journal of virology. 1990 Academic Article GET IT
Times cited: 6
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 66
Nobel lecture. Retroviruses and oncogenes. I. Bioscience reports. 1990 Review GET IT
Times cited: 22
Mechanism of translation of the hepadnaviral polymerase (P) gene. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 33
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature. 1990 Academic Article GET IT
Times cited: 246
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 107
The src protein contains multiple domains for specific attachment to membranes. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 78
Structure and variability of human chromosome ends. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 718
Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus-infected patients. Hepatology (Baltimore, Md.). 1989 Academic Article GET IT
Times cited: 11
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Times cited: 30
DNA of Rous sarcoma virus: its nature and significance. Science (New York, N.Y.). 1972 Academic Article GET IT
Times cited: 17
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). Proceedings of the National Academy of Sciences of the United States of America. 1972 Academic Article GET IT
Times cited: 91
Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus. Nature: New biology. 1971 Academic Article GET IT
Times cited: 36
Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. The Journal of biological chemistry. 1971 Academic Article GET IT
Times cited: 20
Regulation of lac mRNA synthesis in a soluble cell-free system. Nature: New biology. 1971 Academic Article GET IT
Times cited: 48
Regulation of lac transcription in antibiotic-treated E. coli. Nature: New biology. 1971 Academic Article GET IT
Times cited: 38
Regulation of gene expression in Escherichia coli by cyclic AMP. Recent progress in hormone research. 1971 Review GET IT
Times cited: 1
Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. The Journal of biological chemistry. 1970 Academic Article GET IT
Times cited: 10
Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. The Journal of biological chemistry. 1970 Academic Article GET IT
Times cited: 30
Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. Biochemical and biophysical research communications. 1970 Academic Article GET IT
Times cited: 26
Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. The Journal of biological chemistry. 1969 Academic Article GET IT
Times cited: 76

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Research

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Funding awarded

Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells awarded by National Cancer Institute Principal Investigator 2018 - 2024
Addgene 704897 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Weill Cornell Medicine (WCM) SPORE in Prostate Cancer awarded by National Cancer Institute Key Personnel 2017 - 2023

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Background

education and training

M.D., Columbia University College of Physicians and Surgeons 1966
M.A., Harvard University 1962
B.A., Amherst College 1961

Contact

full name

Harold E. Varmus

primary email

varmus@med.cornell.edu

VIVO Weill Cornell Medical College

Harold E. Varmus Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email