Directing two-way traffic in the kidney: A tale of two ions. Academic Article uri icon

Overview

abstract

  • The kidneys regulate levels of Na+ and K+ in the body by varying urinary excretion of the electrolytes. Since transport of each of the two ions can affect the other, controlling both at the same time is a complex task. The kidneys meet this challenge in two ways. Some tubular segments change the coupling between Na+ and K+ transport. In addition, transport of Na+ can shift between segments where it is coupled to K+ reabsorption and segments where it is coupled to K+ secretion. This permits the kidney to maintain electrolyte balance with large variations in dietary intake.

publication date

  • September 1, 2022

Research

keywords

  • Kidney
  • Sodium

Identity

PubMed Central ID

  • PMC9437110

Scopus Document Identifier

  • 85137136532

Digital Object Identifier (DOI)

  • 10.1016/j.semnephrol.2013.04.005

PubMed ID

  • 36048011

Additional Document Info

volume

  • 154

issue

  • 10