Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver. Review uri icon

Overview

abstract

  • Liver regeneration occurs in response to diverse injuries and is capable of functionally reestablishing the lost parenchyma. This phenomenon has been known since antiquity, encapsulated in the Greek myth where Prometheus was to be punished by Zeus for sharing the gift of fire with humanity by having an eagle eat his liver daily, only to have the liver regrow back, thus ensuring eternal suffering and punishment. Today, this process is actively leveraged clinically during living donor liver transplantation whereby up to a two-thirds hepatectomy (resection or removal of part of the liver) on a donor is used for transplant to a recipient. The donor liver rapidly regenerates to recover the lost parenchymal mass to form a functional tissue. This astonishing regenerative process and unique capacity of the liver are examined in further detail in this review.

publication date

  • October 21, 2022

Research

keywords

  • Liver Transplantation

Identity

PubMed Central ID

  • PMC9918695

Scopus Document Identifier

  • 85147895660

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.aan1230

PubMed ID

  • 36270290

Additional Document Info

volume

  • 85