Friend turned foe: TREM2 agonist in battles against tau. Editorial Article uri icon

Overview

abstract

  • In this important study, Jain et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220654) find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD mice seeded with Alzheimer's disease tau.

publication date

  • November 18, 2022

Research

keywords

  • Alzheimer Disease
  • Graft vs Host Disease

Identity

PubMed Central ID

  • PMC9680035

Scopus Document Identifier

  • 85142402773

Digital Object Identifier (DOI)

  • 10.1038/s41467-019-09118-9

PubMed ID

  • 36399126

Additional Document Info

volume

  • 220

issue

  • 1