Gan, Li

Publications

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selected publications

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv : the preprint server for biology. 2023 Article GET IT
Times cited: 626
Autophagy prevents microglial senescence. Nature cell biology. 2023 Academic Article GET IT
Times cited: 10
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience. 2023 Academic Article GET IT
Times cited: 1
Transposable elements and Alzheimer's disease pathogenesis. Trends in neurosciences. 2022 Academic Article GET IT
Times cited: 2
Friend turned foe: TREM2 agonist in battles against tau. The Journal of experimental medicine. 2022 Editorial Article GET IT
Times cited: 1
X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women. Cell. 2022 Academic Article GET IT
Times cited: 17
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nature neuroscience. 2022 Academic Article GET IT
Times cited: 29
The Application of Artificial Neural Network Combined with Virtual Reality Technology in Environment Art Design. Computational intelligence and neuroscience. 2022 Academic Article GET IT
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. 2022 Academic Article GET IT
Times cited: 40
Familial natural short sleep mutations reduce Alzheimer pathology in mice. iScience. 2022 Academic Article GET IT
Times cited: 26
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 15
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy. Science advances. 2022 Academic Article GET IT
Times cited: 38
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022 Academic Article GET IT
Times cited: 49
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science translational medicine. 2021 Academic Article GET IT
Times cited: 22
New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia. Current opinion in neurobiology. 2021 Review GET IT
Times cited: 7
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature communications. 2021 Academic Article GET IT
Times cited: 63
Reducing acetylated tau is neuroprotective in brain injury. Cell. 2021 Academic Article GET IT
Times cited: 44
Sex Differences in Neurodegeneration: The Role of the Immune System in Humans. Biological psychiatry. 2021 Review GET IT
Times cited: 15
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain. eLife. 2020 Academic Article GET IT
Times cited: 32
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. Scientific reports. 2020 Academic Article GET IT
Times cited: 10
Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors. Nano letters. 2020 Academic Article GET IT
Times cited: 10
Astrocyte senescence promotes glutamate toxicity in cortical neurons. PloS one. 2020 Academic Article GET IT
Times cited: 87
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Molecular neurodegeneration. 2020 Academic Article GET IT
Times cited: 54
Microglial microRNAs mediate sex-specific responses to tau pathology. Nature neuroscience. 2019 Academic Article GET IT
Times cited: 55
Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. Acta neuropathologica communications. 2019 Academic Article GET IT
Times cited: 20
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem cell reports. 2019 Academic Article GET IT
Times cited: 34
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. 2019 Academic Article GET IT
Times cited: 61
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nature genetics. 2019 Academic Article GET IT
Times cited: 80
Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?. Trends in molecular medicine. 2019 Review GET IT
Times cited: 51
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain. PLoS biology. 2019 Academic Article GET IT
Times cited: 84
An exercise-induced messenger boosts memory in Alzheimer's disease. Nature medicine. 2019 Comment GET IT
Times cited: 9
Regulation of Tau Homeostasis and Toxicity by Acetylation. Advances in experimental medicine and biology. 2019 Review GET IT
Times cited: 11
Military-related risk factors for dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2018 Review GET IT
Times cited: 7
Converging pathways in neurodegeneration, from genetics to mechanisms. Nature neuroscience. 2018 Review GET IT
Times cited: 230
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 80
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 Review GET IT
Times cited: 77
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Current protocols in cell biology. 2018 Academic Article GET IT
Times cited: 100
Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease. Current opinion in neurobiology. 2018 Review GET IT
Times cited: 65
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 Academic Article GET IT
Times cited: 121
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 Academic Article GET IT
Times cited: 85
TREM2 and Amyloid Beta: A Love-Hate Relationship. Neuron. 2018 Comment GET IT
Times cited: 14
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem cell reports. 2017 Academic Article GET IT
Times cited: 60
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. Current opinion in neurobiology. 2017 Review GET IT
Times cited: 70
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem cell reports. 2017 Academic Article GET IT
Times cited: 134
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. The Journal of biological chemistry. 2017 Academic Article GET IT
Times cited: 87
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimer's & dementia (New York, N. Y.). 2017 Academic Article GET IT
Times cited: 25
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 70
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. Science translational medicine. 2017 Academic Article GET IT
Times cited: 124
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology. 2017 Review GET IT
Times cited: 43
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Molecular neurodegeneration. 2016 Academic Article GET IT
Times cited: 92
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor. Glia. 2016 Review GET IT
Times cited: 120
Targeting microglia for the treatment of Alzheimer's Disease. Glia. 2016 Review GET IT
Times cited: 132
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Academic Article GET IT
Times cited: 155
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature medicine. 2015 Academic Article GET IT
Times cited: 330
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists. Biochemical pharmacology. 2015 Academic Article GET IT
Times cited: 12
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 176
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nature medicine. 2014 Academic Article GET IT
Times cited: 170
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 71
Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Frontiers in aging neuroscience. 2013 Review GET IT
Times cited: 92
Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochimica et biophysica acta. 2013 Academic Article GET IT
Times cited: 47
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta neuropathologica. 2013 Academic Article GET IT
Times cited: 79
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 217
Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 80
Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience. 2012 Academic Article GET IT
Times cited: 5
Selective targeting of microglia by quantum dots. Journal of neuroinflammation. 2012 Academic Article GET IT
Times cited: 59
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β. Journal of neuroinflammation. 2011 Academic Article GET IT
Times cited: 78
Protective effects and mechanisms of sirtuins in the nervous system. Progress in neurobiology. 2011 Review GET IT
Times cited: 169
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 201
Manipulation of gene expression in the central nervous system with lentiviral vectors. Methods in molecular biology (Clifton, N.J.). 2011 Academic Article GET IT
Times cited: 7
Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Academic Article GET IT
Times cited: 707
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell stem cell. 2009 Academic Article GET IT
Times cited: 163
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron. 2008 Academic Article GET IT
Times cited: 173
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nature neuroscience. 2008 Academic Article GET IT
Times cited: 288
Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 2008 Review GET IT
Times cited: 162
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease. Drug news & perspectives. 2007 Review GET IT
Times cited: 25
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 2006 Academic Article GET IT
Times cited: 337
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 671
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing research. 2005 Review GET IT
Times cited: 57
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. Journal of neurochemistry. 2004 Academic Article GET IT
Times cited: 35
New non-viral method for gene transfer into primary cells. Methods (San Diego, Calif.). 2004 Academic Article GET IT
Times cited: 201
Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 119
Localization of the Slack potassium channel in the rat central nervous system. The Journal of comparative neurology. 2002 Academic Article GET IT
Times cited: 138
Specific interference with gene expression and gene function mediated by long dsRNA in neural cells. Journal of neuroscience methods. 2002 Academic Article GET IT
Times cited: 57
Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter. Journal of neurochemistry. 1999 Academic Article GET IT
Times cited: 16
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 79
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature neuroscience. 1998 Academic Article GET IT
Times cited: 140
When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons. Journal of neurobiology. 1998 Review GET IT
Times cited: 91
Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. The Journal of physiology. 1998 Academic Article GET IT
Times cited: 292
Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 44
Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. Journal of neurophysiology. 1995 Academic Article GET IT
Times cited: 102

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Research

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Co-investigator Network

Funding awarded

cGAS inhibitors for Alzheimer''s disease treatment awarded by National Institute on Aging Principal Investigator 2021 - 2026
Maladaptive Antiviral Pathways In Alzheimer''S Disease awarded by National Institute on Aging Principal Investigator 2021 - 2026
Targeting maladaptive innate immune response to treat PD awarded by JPB Foundation, The Principal Investigator 2021 - 2024
Human cGAS small molecule inhibitors awarded by Cure Alzheimer’s Fund Principal Investigator 2021 - 2024
Rainwater awarded by Rainwater Charitable Foundation Principal Investigator 2022 - 2023
Rainwater awarded by Rainwater Charitable Foundation Principal Investigator 2022 - 2023
Addgene 703132 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 698729 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 697783 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 696309 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Development of cGAS Inhibitors to Treat Neurodegenerative Diseases awarded by Daedalus Fund for Innovation (Weill Cornell) Principal Investigator 2021 - 2023
Sadaf Amin''s BrightFocus Fellowship, "The Role of cGAS-STING Signaling in Neuroinflammation and Alzheimer''s Disease" awarded by BrightFocus Foundation Principal Investigator 2020 - 2023
Tau acetylation in Alzheimer''s disease awarded by National Institute on Aging Principal Investigator 2019 - 2023
Linking tau proteostasis with neuronal activity in FTD awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2018 - 2023

TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimer''s Disease awarded by National Institute on Aging Co-Investigator 2022 - 2027
Structure and Function of Tau awarded by National Institute on Aging Co-Investigator 2020 - 2024
The Role of Transposable Elements in Healthy Aging and in Alzheimer''s Disease awarded by National Institute on Aging Co-Investigator 2022 - 2023

Trem2-APOE Pathway in Alzheimer''s Disease: Exploring the differential effects of R47H on the APOE3 and APOE4 backgrounds in a tauopathy model awarded by National Institute on Aging Key Personnel 2022 - 2025
Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer''s disease awarded by National Institute on Aging Key Personnel 2020 - 2025

Study of Selective Cell and System Vulnerability in Alzheimer''s Disease awarded by Chan Zuckerberg Initiative Principal Investigator Subaward 2023 - 2028
Development of novel genomic approaches for profiling cellular temporal-spatial dynamics of neurogenesis in Aging and Alzheimer''s disease awarded by Bill & Melinda Gates Foundation Principal Investigator Subaward 2022 - 2027
Genome-wide identification and characterization of Alzheimer''s Disease-associated enhancers awarded by National Institute of General Medical Sciences Principal Investigator Subaward 2022 - 2027
Elucidate the Roles of Alzheimer''s Disease Variants in Gene Expression and AD Phenotypes awarded by National Institute on Aging Principal Investigator Subaward 2022 - 2025
Exploring HIV-associated Neurocognitive Disorder (HAND) and HIV Latency at the Single Cell Level in Cerebral Organoids awarded by National Institute on Drug Abuse Principal Investigator Subaward 2020 - 2024
Study of Selective Cell and System Vulnerability in Alzheimer''s Disease awarded by Chan Zuckerberg Initiative Principal Investigator Subaward 2022 - 2023

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Background

education and training

Ph.D., Yale University School of Medicine 1996
B.S., Peking University (China) 1990

Contact

full name

Li Gan

primary email

lig2033@med.cornell.edu

VIVO Weill Cornell Medical College

Li Gan Director, Helen and Robert Appel Alzheimer’s Disease Research Institute

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email