Spatial omics technologies at multimodal and single cell/subcellular level. Review uri icon

Overview

abstract

  • Spatial omics technologies enable a deeper understanding of cellular organizations and interactions within a tissue of interest. These assays can identify specific compartments or regions in a tissue with differential transcript or protein abundance, delineate their interactions, and complement other methods in defining cellular phenotypes. A variety of spatial methodologies are being developed and commercialized; however, these techniques differ in spatial resolution, multiplexing capability, scale/throughput, and coverage. Here, we review the current and prospective landscape of single cell to subcellular resolution spatial omics technologies and analysis tools to provide a comprehensive picture for both research and clinical applications.

publication date

  • December 13, 2022

Research

keywords

  • Genomics
  • Proteomics

Identity

PubMed Central ID

  • PMC9746133

Scopus Document Identifier

  • 85144124644

Digital Object Identifier (DOI)

  • 10.1186/s13059-022-02824-6

PubMed ID

  • 36514162

Additional Document Info

volume

  • 23

issue

  • 1