Development of a New Methodology for Dearomative Borylation of Coumarins and Chromenes and Its Applications to Synthesize Boron-Containing Retinoids. Academic Article uri icon

Overview

abstract

  • Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation process to synthesize boron-containing oxacycles. In this report, the borylation of coumarins, chromones, and chromenes comprising functional groups, such as esters, nitriles, carbonyls, and amides, has been achieved. In addition, the method generates different classes of potential boron-based retinoids, including the ones with oxadiazole and anthocyanin motifs. The borylated oxacycles can serve as suitable intermediates to generate a library of compounds.

publication date

  • January 20, 2023

Research

keywords

  • Benzopyrans
  • Boron

Identity

PubMed Central ID

  • PMC9921500

Scopus Document Identifier

  • 85147894093

Digital Object Identifier (DOI)

  • 10.1016/j.tetlet.2011.12.118

PubMed ID

  • 36770721

Additional Document Info

volume

  • 28

issue

  • 3