EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort. Academic Article uri icon

Overview

abstract

  • The objective of this multicenter retrospective study was to examine the incidence, patient characteristics, pathology, and outcomes associated with Epstein-Barr virus (EBV)-related CNS lymphoma (CNSL) in older patients. Among 309 CNSL patients aged ≥60, 11.7% had EBV + tumors of which 72.2% were solid organ transplant (SOT)-related post-transplant lymphoproliferative disorders (PTLD). Younger age, SOT or autoimmune disease, and immunosuppressive treatment correlated highly with EBV-positivity. EBV + tumors were associated with absent C-MYC and BCL6 expression. EBV + PTLD was more likely to be associated with the absence of CD5 expression. EBV + non-PTLD had better median OS (not reached) compared to EBV + PTLD (10.8 months) and EBV-negative patients (43 months). Multivariable Cox regression analysis showed that age, performance status, and PTLD were negative predictors of OS. EBV status and immunosuppressive treatment were not correlated with OS. Our findings merit further investigation of EBV + PCNSL tumors and EBV-directed therapies.

authors

  • Agrawal, Prashasti
  • David, Kevin A
  • Chen, Zhengming
  • Sundaram, Suchitra
  • Kim, Seo-Hyun
  • Vaca, Ryan
  • Lin, Yong
  • Singer, Samuel
  • Malecek, Mary-Kate
  • Carter, Jordan
  • Zayac, Adam
  • Kim, Myung Sun
  • Reddy, Nishitha
  • Ney, Douglas
  • Habib, Alma
  • Strouse, Christopher
  • Graber, Jerome
  • Bachanova, Veronika
  • Salman, Sidra
  • Vendiola, Jean A
  • Hossain, Nasheed
  • Tsang, Mazie
  • Major, Ajay
  • Gandhi, Maher K
  • Keane, Colm
  • Bond, David A
  • Folstad, Matthew
  • Chang, Julie
  • Mier-Hicks, Angel
  • Torka, Pallawi
  • Rajakumar, Priya
  • Venugopal, Parameswaran
  • Berg, Stephanie
  • Glantz, Michael
  • Goldlust, Samuel A
  • Matnani, Rahul
  • Kumar, Pallavi
  • Ollila, Thomas A
  • Cai, Johnny
  • Spurgeon, Stephen E
  • Sieg, Alex G
  • Cleveland, Joseph
  • Epperla, Narendranath
  • Karmali, Reem
  • Naik, Seema
  • Smith, Sonali M
  • Rubenstein, James L
  • Kahl, Brad S
  • Chadburn, Amy
  • Evens, Andrew M
  • Martin, Peter

publication date

  • March 24, 2023

Research

keywords

  • Epstein-Barr Virus Infections
  • Lymphoma
  • Lymphoproliferative Disorders

Identity

Scopus Document Identifier

  • 85150971844

Digital Object Identifier (DOI)

  • 10.1080/10428194.2023.2191152

PubMed ID

  • 36960939

Additional Document Info

volume

  • 64

issue

  • 5