A novel vasodepressor response elicited from the rat cerebellar fastigial nucleus: the fastigial depressor response. Academic Article uri icon

Overview

abstract

  • We sought to determine by using kainic acid (KA), an agent stimulating neuronal cell bodies but not fibers, whether the elevations in arterial pressure (AP) and heart rate (HR) elicited by electrical stimulation of the cerebellar fastigial nucleus (FN) are due to excitation of local neurons in FN or fibers passing through the area. Rats were anesthetized (chloralose 40 mg/kg), paralyzed (tubocurarine) and artificially ventilated. Electrical stimulation of FN (50 Hz, 10-100 microA) increased AP and HR. In contrast restricted microinjections of KA (0.05-5 nmol/100 nl) in FN elicited a sustained, dose-dependent decrease in AP and HR. The response is not due to diffusion of KA to adjacent sites. Excitation by KA of neurons intrinsic to FN elicits a heretofore unrecognized vasodepressor response, the fastigial depressor response.

publication date

  • April 9, 1986

Research

keywords

  • Blood Pressure
  • Cerebellar Nuclei
  • Heart Rate

Identity

Scopus Document Identifier

  • 0022532173

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(86)90498-1

PubMed ID

  • 3708335

Additional Document Info

volume

  • 370

issue

  • 2