Cachexia: A systemic consequence of progressive, unresolved disease. Review uri icon

Overview

abstract

  • Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.

publication date

  • April 27, 2023

Research

keywords

  • Cachexia

Identity

Scopus Document Identifier

  • 85153052207

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2023.03.028

PubMed ID

  • 37116469

Additional Document Info

volume

  • 186

issue

  • 9