Goncalves, Marcus DaSilva

Publications

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selected publications

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. Cell metabolism. 2023 Academic Article GET IT
Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei Sequencing. bioRxiv : the preprint server for biology. 2023 Article GET IT
Times cited: 269
Cachexia: A systemic consequence of progressive, unresolved disease. Cell. 2023 Review GET IT
Times cited: 1
Sodium-Glucose Cotransporter-2 Inhibitors for Hyperglycemia in Phosphoinositide 3-kinase Pathway Inhibition. Research square. 2023 Article GET IT
Times cited: 26
An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 Academic Article GET IT
Times cited: 19
Live cold to grow old? Thermogenesis to fight cancer. Cell research. 2022 Comment GET IT
Selective targeting of visceral adiposity by polycation nanomedicine. Nature nanotechnology. 2022 Academic Article GET IT
Times cited: 4
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Science immunology. 2022 Academic Article GET IT
Times cited: 8
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nature communications. 2022 Academic Article GET IT
Times cited: 5
Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer. Frontiers in oncology. 2022 Academic Article GET IT
Times cited: 47
Developing dietary interventions as therapy for cancer. Nature reviews. Cancer. 2022 Review GET IT
Times cited: 27
Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment. Cancer medicine. 2022 Academic Article GET IT
Diabetes Epidemiology Among Adults in Port-au-Prince, Haiti: A Cross-Sectional Study. Frontiers in endocrinology. 2022 Academic Article GET IT
Times cited: 9
Management of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia. Integrative cancer therapies. 2022 Academic Article GET IT
Times cited: 1
A multidisciplinary approach to optimizing care of patients treated with alpelisib. Breast (Edinburgh, Scotland). 2021 Review GET IT
Times cited: 5
Dietary fructose improves intestinal cell survival and nutrient absorption. Nature. 2021 Academic Article GET IT
Times cited: 76
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase. Cancer & metabolism. 2021 Academic Article GET IT
Times cited: 47
Treating Alpelisib-Induced Hyperglycemia with Very Low Carbohydrate Diets and Sodium-Glucose Co-Transporter 2 Inhibitors: A Case Series. Integrative cancer therapies. 2021 Review GET IT
Times cited: 9
Engineered diets to improve cancer outcomes. Current opinion in biotechnology. 2020 Review GET IT
Times cited: 7
The effects of neoadjuvant chemotherapy and interval debulking surgery on body composition in patients with ovarian cancer. JCSM clinical reports. 2020 Academic Article GET IT
A machine learning and network framework to discover new indications for small molecules. PLoS computational biology. 2020 Academic Article GET IT
Times cited: 8
A 'fast'er way to treat breast cancer. Nature metabolism. 2020 Academic Article GET IT
Times cited: 1
Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. Nature reviews. Endocrinology. 2020 Review GET IT
Times cited: 109
High-fructose corn syrup enhances intestinal tumor growth in mice. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 176
Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer. Cancers. 2019 Academic Article GET IT
Times cited: 65
Optimal Management of Adverse Events From Copanlisib in the Treatment of Patients With Non-Hodgkin Lymphomas. Clinical lymphoma, myeloma & leukemia. 2018 Academic Article GET IT
Times cited: 31
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer. The New England journal of medicine. 2018 Conference Paper GET IT
Times cited: 153
Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018 Academic Article GET IT
Times cited: 2
Computed tomography-derived assessments of regional muscle volume: Validating their use as predictors of whole body muscle volume in cancer patients. The British journal of radiology. 2018 Academic Article GET IT
Times cited: 9
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018 Academic Article GET IT
Times cited: 353
A Glycolysis Outsider Steps into the Cancer Spotlight. Cell metabolism. 2018 Comment GET IT
Times cited: 14
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular cell. 2018 Academic Article GET IT
Times cited: 48
Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 65
Imaging skeletal muscle volume, density, and FDG uptake before and after induction therapy for non-small cell lung cancer. Clinical radiology. 2018 Academic Article GET IT
Times cited: 9
Regional Variation in Skeletal Muscle and Adipose Tissue FDG Uptake Using PET/CT and Their Relation to BMI. Academic radiology. 2017 Academic Article GET IT
Times cited: 7
Obesity and Cancer Mechanisms: Cancer Metabolism. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Review GET IT
Times cited: 186
A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body-A Prospective Pilot Study. Academic radiology. 2016 Academic Article GET IT
Times cited: 8
FDG-PET/CT assessment of differential chemotherapy effects upon skeletal muscle metabolism in patients with melanoma. Annals of nuclear medicine. 2014 Academic Article GET IT
Times cited: 5
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 904
Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne muscular dystrophy. The American journal of pathology. 2011 Academic Article GET IT
Times cited: 78
Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition. PloS one. 2010 Academic Article GET IT
Times cited: 47
The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. International journal of obesity (2005). 2009 Academic Article GET IT
Times cited: 105
The treatment of night eating: the patient's perspective. European eating disorders review : the journal of the Eating Disorders Association. 2009 Academic Article GET IT
Times cited: 13
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Current biology : CB. 2008 Academic Article GET IT
Times cited: 53

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Research

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Funding awarded

Combination Therapies Targeting Insulin Signaling in Endometrial Cancer awarded by National Cancer Institute Principal Investigator 2023 - 2028
The CANcer Cachexia Action Network (CANCAN): a Multidisciplinary Virtual Institute with the Mission to Cure Cancer Cachexia awarded by Cancer Research UK Principal Investigator 2022 - 2027
The role of PKM2 in dietary lipid absorption and fructose-induced obesity awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2027
Molecular Mechanisms of Fructose-induced Colorectal Cancer Cell Survival awarded by National Cancer Institute Principal Investigator 2022 - 2026
The CANcer Cachexia Action Network (CANCAN): a Multidisciplinary Virtual Institute with the Mission to Cure Cancer Cachexia awarded by National Cancer Institute Principal Investigator 2022 - 2024
Leveraging Thermogenic Silencers as Potent Treatment Options to Combat Cancer-Anorexia-Cachexia-Syndrome (CACS) awarded by National Institute of General Medical Sciences Principal Investigator 2023 - 2023
Targeting Insulin to Improve Endometrial Cancer awarded by American Association for Cancer Research Principal Investigator 2020 - 2023

Insulin-suppressing diets to reduce breast cancer risk and mortality awarded by Susan G. Komen Breast Cancer Foundation, Inc. Co-Investigator 2022 - 2024

Research Training in Endocrinology and Metabolism awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2023 - 2028
Turning insulin addiction and KRAS/BRCA2 co-mutations into vulnerabilities for pancreatic cancer treatment awarded by Fondazione AIRC per la Ricerca sul Cancro Key Personnel 2022 - 2024

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Background

education and training

M.D., University of Pennsylvania School of Medicine 2012
Ph.D., University of Pennsylvania School of Medicine 2010
M.S.E., The Johns Hopkins University 2006
B.S., The Johns Hopkins University 2004

Contact

full name

Marcus DaSilva Goncalves

primary email

mdg9010@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Marcus DaSilva Goncalves Assistant Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage