Tumor-derived nanoseeds condition the soil for metastatic organotropism. Review uri icon

Overview

abstract

  • Primary tumors secrete a variety of factors to turn distant microenvironments into favorable and fertile 'soil' for subsequent metastases. Among these 'seeding' factors that initiate pre-metastatic niche (PMN) formation, tumor-derived extracellular vesicles (EVs) are of particular interest as tumor EVs can direct organotropism depending on their surface integrin profiles. In addition, EVs also contain versatile, bioactive cargo, which include proteins, metabolites, lipids, RNA, and DNA fragments. The cargo incorporated into EVs is collectively shed from cancer cells and cancer-associated stromal cells. Increased understanding of how tumor EVs promote PMN establishment and detection of EVs in bodily fluids highlight how tumor EVs could serve as potential diagnostic and prognostic biomarkers, as well as provide a therapeutic target for metastasis prevention. This review focuses on tumor-derived EVs and how they direct organotropism and subsequently modulate stromal and immune microenvironments at distal sites to facilitate PMN formation. We also outline the progress made thus far towards clinical applications of tumor EVs.

publication date

  • May 12, 2023

Research

keywords

  • Extracellular Vesicles
  • Neoplasms

Identity

Scopus Document Identifier

  • 85162268540

Digital Object Identifier (DOI)

  • 10.1016/j.semcancer.2023.05.003

PubMed ID

  • 37178822

Additional Document Info

volume

  • 93