Lyden, David C

Publications

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selected publications

Updates on radiotherapy-immunotherapy combinations: Proceedings of 6^th annual ImmunoRad conference. Oncoimmunology. 2023 Review GET IT
Times cited: 511
Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature. 2023 Academic Article GET IT
Times cited: 1
Tumor-derived nanoseeds condition the soil for metastatic organotropism. Seminars in cancer biology. 2023 Review GET IT
Collection of Biospecimens from the Inspiration4 Mission Establishes the Standards for the Space Omics and Medical Atlas (SOMA). bioRxiv : the preprint server for biology. 2023 Article GET IT
Times cited: 359
The capture of extracellular vesicles endogenously released by xenotransplanted tumours induces an inflammatory reaction in the premetastatic niche. Journal of extracellular vesicles. 2023 Academic Article GET IT
Genomic mapping of metastatic organotropism in lung adenocarcinoma. Cancer cell. 2023 Academic Article GET IT
Times cited: 1
Immune determinants of the pre-metastatic niche. Cancer cell. 2023 Review GET IT
Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism. bioRxiv : the preprint server for biology. 2023 Article GET IT
Protocol for Plasma Extracellular Vesicle and Particle Isolation and Mass Spectrometry-Based Proteomic Identification. Methods in molecular biology (Clifton, N.J.). 2023 Academic Article GET IT
Detection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer. Frontiers in oncology. 2022 Academic Article GET IT
Times cited: 32
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature communications. 2022 Academic Article GET IT
Times cited: 8
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications. 2022 Academic Article GET IT
Times cited: 1
Extracellular vesicles and particles impact the systemic landscape of cancer. The EMBO journal. 2022 Review GET IT
Times cited: 12
ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance. NPJ breast cancer. 2022 Academic Article GET IT
Times cited: 28304
Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems. Clinical & experimental metastasis. 2022 Academic Article GET IT
Metastasis. Cancer cell. 2022 Academic Article GET IT
Times cited: 4
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain. Nature cancer. 2021 Academic Article GET IT
Times cited: 24
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nature cancer. 2021 Academic Article GET IT
Times cited: 31
Calcium signaling induces a partial EMT. EMBO reports. 2021 Academic Article GET IT
Times cited: 17
Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. The Journal of experimental medicine. 2021 Review GET IT
Times cited: 31
The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Molecular oncology. 2021 Academic Article GET IT
Times cited: 11
KRAS ^G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 13
A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma. JAMA surgery. 2021 Academic Article GET IT
Times cited: 35
Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles. Cancer research. 2021 Academic Article GET IT
Times cited: 36
An exosome pathway without an ESCRT. Cell research. 2021 Comment GET IT
Times cited: 28
Tumour-regulated anorexia preceding cachexia. Nature cell biology. 2021 Comment GET IT
Times cited: 4
Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids. STAR protocols. 2020 Academic Article GET IT
Times cited: 8
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers. iScience. 2020 Academic Article GET IT
Times cited: 19
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Academic Article GET IT
Times cited: 477
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell stem cell. 2020 Academic Article GET IT
Times cited: 420
Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases. Future oncology (London, England). 2020 Academic Article GET IT
Times cited: 17
Non-reversible tissue fixation retains extracellular vesicles for in situ imaging. Nature methods. 2019 Academic Article GET IT
Times cited: 13
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nature cell biology. 2019 Academic Article GET IT
Times cited: 199
Tumour vesicular micromachinery uncovered. Nature cell biology. 2019 Article GET IT
Times cited: 5
Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments. Cancer immunology research. 2019 Academic Article GET IT
Times cited: 22
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease. Nature communications. 2019 Academic Article GET IT
Times cited: 94
Exosome-Mediated Metastasis: Communication from a Distance. Developmental cell. 2019 Review GET IT
Times cited: 621
Correction: Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer. PloS one. 2019 Article GET IT
Times cited: 1
Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization. Nature protocols. 2019 Academic Article GET IT
Times cited: 204
Tumor Extracellular Vesicles Impede Interferon Alert Responses. Cancer cell. 2019 Comment GET IT
Times cited: 2
Engineered niches model the onset of metastasis. Nature biomedical engineering. 2018 Comment GET IT
Times cited: 3
Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer. PloS one. 2018 Academic Article GET IT
Times cited: 14
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression. Science advances. 2018 Academic Article GET IT
Times cited: 120
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature cell biology. 2018 Academic Article GET IT
Times cited: 887
Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer. HPB : the official journal of the International Hepato Pancreato Biliary Association. 2018 Academic Article GET IT
Times cited: 48
Bone voyage-Osteoblasts remotely control tumors. Science (New York, N.Y.). 2017 Comment GET IT
Times cited: 4
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 408
A phase II study of radioimmunotherapy with intraventricular ¹³¹ I-3F8 for medulloblastoma. Pediatric blood & cancer. 2017 Academic Article GET IT
Times cited: 40
Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis. Pediatric blood & cancer. 2017 Academic Article GET IT
Times cited: 14
Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis. Cell. 2017 Comment GET IT
Times cited: 32
Metastasis: Lymphatic detours for cancer. Nature. 2017 Comment GET IT
Times cited: 8
A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors. PloS one. 2017 Academic Article GET IT
Times cited: 28
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 26
Pre-metastatic niches: organ-specific homes for metastases. Nature reviews. Cancer. 2017 Review GET IT
Times cited: 1033
Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles. Cancer research. 2017 Academic Article GET IT
Times cited: 98
A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors. Pediatric blood & cancer. 2016 Academic Article GET IT
Times cited: 49
Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Academic Article GET IT
Times cited: 19
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. Cancer cell. 2016 Review GET IT
Times cited: 1130
Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature medicine. 2016 Academic Article GET IT
Times cited: 29
The Effect of Cage Shape on Nanoparticle-Based Drug Carriers: Anticancer Drug Release and Efficacy via Receptor Blockade Using Dextran-Coated Iron Oxide Nanocages. Nano letters. 2016 Academic Article GET IT
Times cited: 67
Pre-Metastatic Niche Formation Has Taken Its TOLL. Cancer cell. 2016 Comment GET IT
Times cited: 12
JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors. Science signaling. 2016 Academic Article GET IT
Times cited: 50
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. The Lancet. Oncology. 2016 Academic Article GET IT
Times cited: 223
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nature communications. 2016 Academic Article GET IT
Times cited: 130
Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016 Academic Article GET IT
Times cited: 226
Cancer Exosomes as Mediators of Drug Resistance. Methods in molecular biology (Clifton, N.J.). 2016 Academic Article GET IT
Times cited: 18
Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre-metastatic Niche. Cancer research. 2015 Academic Article GET IT
Times cited: 98
Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Academic Article GET IT
Times cited: 3102
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature cell biology. 2015 Academic Article GET IT
Times cited: 1775
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation. Nature communications. 2015 Academic Article GET IT
Times cited: 72
Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone marrow transplantation. 2015 Academic Article GET IT
Times cited: 63
Medulloblastoma subgroups remain stable across primary and metastatic compartments. Acta neuropathologica. 2015 Academic Article GET IT
Times cited: 71
Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell research. 2014 Letter GET IT
Times cited: 1141
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization. Oncogene. 2014 Academic Article GET IT
Times cited: 69
Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine. Advanced materials (Deerfield Beach, Fla.). 2014 Academic Article GET IT
Times cited: 127
Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier. Cancer research. 2013 Academic Article GET IT
Times cited: 40
Roadblocks to translational advances on metastasis research. Nature medicine. 2013 Academic Article GET IT
Times cited: 59
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 329
The evolution of the cancer niche during multistage carcinogenesis. Nature reviews. Cancer. 2013 Review GET IT
Times cited: 210
The perivascular niche regulates breast tumour dormancy. Nature cell biology. 2013 Academic Article GET IT
Times cited: 777
Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. Molecular biology of the cell. 2013 Academic Article GET IT
Times cited: 73
Molecular diagnostics in paediatric glial tumours. The Lancet. Oncology. 2013 Review GET IT
Times cited: 8
STAT3 negatively regulates thyroid tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 107
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature medicine. 2012 Academic Article GET IT
Times cited: 2722
Megakaryocytes, malignancy and bone marrow vascular niches. Journal of thrombosis and haemostasis : JTH. 2012 Review GET IT
Times cited: 52
Stat3 mediates expression of autotaxin in breast cancer. PloS one. 2011 Academic Article GET IT
Times cited: 59
A TeNaCious foundation for the metastatic niche. Cancer cell. 2011 Academic Article GET IT
Times cited: 5
Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma. International journal of radiation oncology, biology, physics. 2011 Academic Article GET IT
Times cited: 39
The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Seminars in cancer biology. 2011 Review GET IT
Times cited: 504
Neoangiogenesis contributes to the development of hemophilic synovitis. Blood. 2010 Academic Article GET IT
Times cited: 91
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature. 2010 Academic Article GET IT
Times cited: 585
Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma. Pediatric blood & cancer. 2010 Academic Article GET IT
Times cited: 65
Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas. The Journal of clinical investigation. 2010 Comment GET IT
Times cited: 27
Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 248
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. PloS one. 2009 Academic Article GET IT
Times cited: 28
Gene therapy in skin: choosing the optimal viral vector. Annals of plastic surgery. 2009 Academic Article GET IT
Times cited: 6
The metastatic niche: adapting the foreign soil. Nature reviews. Cancer. 2009 Review GET IT
Times cited: 960
A novel method for targeted gene therapy in ischemic tissues through viral transfection of an expression cassette containing multiple repetitions of hypoxia response element. Plastic and reconstructive surgery. 2009 Academic Article GET IT
Times cited: 4
Inflammation joins the "niche". Cancer cell. 2008 Comment GET IT
Times cited: 42
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas. Proceedings of the National Academy of Sciences of the United States of America. 2008 Letter GET IT
Times cited: 48
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. The Journal of clinical investigation. 2008 Academic Article GET IT
Times cited: 793
A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization. Cancer cell. 2008 Comment GET IT
Times cited: 71
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes & development. 2008 Review GET IT
Times cited: 324
Cancer. A few to flip the angiogenic switch. Science (New York, N.Y.). 2008 Comment GET IT
Times cited: 58
Chapter 11. The role of bone marrow-derived cells in tumor angiogenesis and metastatic progression. Methods in enzymology. 2008 Academic Article GET IT
Times cited: 6
Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arteriosclerosis, thrombosis, and vascular biology. 2007 Review GET IT
Times cited: 57
A phase II trial of carboplatin for intraocular retinoblastoma. Pediatric blood & cancer. 2007 Academic Article GET IT
Times cited: 38
A phase II trial of thalidomide and cyclophosphamide in patients with recurrent or refractory pediatric malignancies. Pediatric blood & cancer. 2007 Academic Article GET IT
Times cited: 14
Niche-to-niche migration of bone-marrow-derived cells. Trends in molecular medicine. 2007 Review GET IT
Times cited: 188
Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer metastasis reviews. 2006 Review GET IT
Times cited: 268
Preparing the "soil": the premetastatic niche. Cancer research. 2006 Review GET IT
Times cited: 506
S100 chemokines mediate bookmarking of premetastatic niches. Nature cell biology. 2006 Comment GET IT
Times cited: 67
Treatment-related myelodysplastic syndrome after chemotherapy for childhood low-grade astrocytoma. Journal of pediatric hematology/oncology. 2006 Letter GET IT
Times cited: 1
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nature medicine. 2006 Academic Article GET IT
Times cited: 564
Priming the 'soil' for breast cancer metastasis: the pre-metastatic niche. Breast disease. 2006 Review GET IT
Times cited: 106
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005 Academic Article GET IT
Times cited: 2539
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 18
AC133/CD133/Prominin-1. The international journal of biochemistry & cell biology. 2005 Review GET IT
Times cited: 321
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nature medicine. 2003 Academic Article GET IT
Times cited: 604
Patterns of failure using a conformal radiation therapy tumor bed boost for medulloblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2003 Academic Article GET IT
Times cited: 86
Primary leptomeningeal primitive neuroectodermal tumor. 2003 GET IT
Times cited: 9
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nature medicine. 2003 Review GET IT
Times cited: 1458
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 1350
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?. Nature reviews. Cancer. 2002 Review GET IT
Times cited: 629
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nature medicine. 2002 Academic Article GET IT
Times cited: 561
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell. 2002 Academic Article GET IT
Times cited: 1524
Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circulation research. 2002 Academic Article GET IT
Times cited: 287
Contribution of marrow-derived progenitors to vascular and cardiac regeneration. Seminars in cell & developmental biology. 2002 Review GET IT
Times cited: 146
Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue. 2002 GET IT
Times cited: 13
A genetic approach to understanding tumor angiogenesis. Cold Spring Harbor symposia on quantitative biology. 2002 Academic Article GET IT
Times cited: 2
The Id proteins and angiogenesis. Oncogene. 2001 Review GET IT
Times cited: 201
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature medicine. 2001 Academic Article GET IT
Times cited: 1652
Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 610
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature. 1999 Academic Article GET IT
Times cited: 781
Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1998 Academic Article GET IT
Times cited: 218
The expanding role of chemotherapy for pediatric supratentorial malignant gliomas. Journal of neuro-oncology. 1996 Review GET IT
Times cited: 3
Variation in susceptibility of Balb/c mice to coxsackievirus group B type 3-induced myocarditis with age. Cellular immunology. 1987 Academic Article GET IT
Times cited: 22
Coxsackievirus B-3-induced myocarditis. Effect of sex steroids on viremia and infectivity of cardiocytes. The American journal of pathology. 1987 Academic Article GET IT
Times cited: 74
Demonstration of suppressor cells in coxsackievirus group B, type 3 infected female Balb/c mice which prevent myocarditis. Cellular immunology. 1986 Academic Article GET IT
Times cited: 9
Immunopathogenesis of experimental Coxsackievirus induced myocarditis: role of autoimmunity. Herz. 1985 Academic Article GET IT
Times cited: 17
Aggravation of coxsackievirus, group B, type 3-induced myocarditis and increase in cellular immunity to myocyte antigens in pregnant Balb/c mice and animals treated with progesterone. Cellular immunology. 1984 Academic Article GET IT
Times cited: 42

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Research

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Co-investigator Network

Funding awarded

Endoxifen Trial Experimental Endpoint SRA awarded by Atossa Therapeutics, Inc. Principal Investigator 2022 - 2026
The Excellence of Science EOS awarded by Fonds de la Recherche Scientifique - FNRS Principal Investigator 2022 - 2025
Systemic regulation of metastasis awarded by National Cancer Institute Principal Investigator 2018 - 2025

Clinical and Translational Science Center - TL1 awarded by National Center for Advancing Translational Sciences Co-Investigator 2022 - 2027

Immune Cells and Secretory Pathways Leading to Human Systemic Autoimmunity awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2019 - 2024
In vitro modeling of blood brain barrier dysfunction on a chip to elucidate the pathogenesis of cerebral malaria awarded by National Heart, Lung, & Blood Institute Key Personnel 2021 - 2023
Exosome-mediated thrombosis in pancreatic cancer awarded by United States Department of Defense Key Personnel 2020 - 2023

Pancreatic Cancer Detection Consortium awarded by National Cancer Institute Principal Investigator Subaward 2022 - 2027
Molecular Regulation of B cells and T cells in Human SLE awarded by Centers for Disease Control & Prevention Principal Investigator Subaward 2019 - 2024

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Background

education and training

M.D., Brown University School of Medicine 1989
Ph.D., University of Vermont 1985
B.S., University of Connecticut 1981

Contact

full name

David C Lyden

primary email

dcl2001@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

David C Lyden Professor of Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage