The graded and quantal nature of opioid analgesia in the rat tailflick assay. Academic Article uri icon

Overview

abstract

  • Opioid agonists routinely increase the latency to respond in the rodent tailflick assay. The nature of this effect was investigated in 5 experiments using several parametric variations and routes of administration. Morphine and methadone were found to produce both quantal and graded effects in all experiments. In cases where quantal effects were observed, the majority of animals also responded in a graded manner during subsequent testing. The increase in latency to respond in the tailflick assay produced by opioid agonists is not accurately characterized as predominantly quantal.

publication date

  • April 8, 1985

Research

keywords

  • Methadone
  • Morphine
  • Pain

Identity

Scopus Document Identifier

  • 0021946350

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(85)91558-6

PubMed ID

  • 3986573

Additional Document Info

volume

  • 331

issue

  • 2