Increased vascular permeability produced by human platelet granule cationic extract. Academic Article uri icon

Overview

abstract

  • A cationic protein extract obtained from isolated human platelet granules increased vascular permeability in mouse and rabbit skin. The permeability-enhancing effect was not inhibited by soybean trypsin and pancreatic trypsin inhibitor, methylsergide maleate, carboxypeptidase B, and C[unk]1 inactivator. Permeability-enhancing activity was blocked by prior treatment of challenged animals with antihistamine. The nondializable relatively heat-stable cationic granule protein extract possessed potent mastocytolytic activity. The experiments described suggest that human platelets exert a permeability-enhancing effect by lysosomal release of cationic proteins which cause histamine release from adjacent tissue mast cells.

publication date

  • February 1, 1970

Research

keywords

  • Blood Platelets
  • Cell Membrane Permeability
  • Proteins
  • Tissue Extracts

Identity

PubMed Central ID

  • PMC322470

Scopus Document Identifier

  • 0014734356

Digital Object Identifier (DOI)

  • 10.1172/JCI106237

PubMed ID

  • 4391559

Additional Document Info

volume

  • 49

issue

  • 2