Dynorphin(1-13) improves survival in cats with focal cerebral ischaemia. Academic Article uri icon

Overview

abstract

  • Since the discovery of opiate receptors in the central nervous system (CNS), it has become apparent that endogenous opiate ligands are involved in CNS function. Most attention has focused on their role in modulating pain, but they have also been implicated in various physiological functions and in disease states. We are concerned with evidence that endogenous opioid peptides may also contribute to the neurological deficits arising from cerebral ischaemia. Dynorphin, which is widely distributed in the brain and pituitary, has been reported to produce unusual motor and behavioural effects and may act as a regulatory neuropeptide, not as a classical opiate agonist or antagonist. We have therefore administered to cats in which the right middle cerebral artery had been occluded both dynorphin (1-13) and analogue and control materials. We find that dynorphin (1-13) prolongs survival.

publication date

  • December 1, 1984

Research

keywords

  • Brain Ischemia
  • Dynorphins
  • Peptide Fragments

Identity

Scopus Document Identifier

  • 0021684695

Digital Object Identifier (DOI)

  • 10.1038/312551a0

PubMed ID

  • 6150441

Additional Document Info

volume

  • 312

issue

  • 5994