Nature

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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. 2018
Behavioural improvements with thalamic stimulation after severe traumatic brain injury. 2007
Reprogramming tumour-associated macrophages to outcompete cancer cells. 2023
Intricate 3D architecture of a DNA mimic of GFP.. 618. 2023
Epigenetic dysregulation from chromosomal transit in micronuclei.. 619. 2023
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.. 618. 2023
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.. 618. 2023
A somato-cognitive action network alternates with effector regions in motor cortex.. 617. 2023
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.. 616. 2023
mRNA ageing shapes the Cap2 methylome in mammalian mRNA.. 614. 2023
An atlas of substrate specificities for the human serine/threonine kinome.. 613. 2023
Ovarian cancer mutational processes drive site-specific immune evasion.. 612. 2022
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.. 612. 2022
A multinational Delphi consensus to end the COVID-19 public health threat.. 611. 2022
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation.. 611. 2022
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces.. 611. 2022
Non-redundant functions of group 2 innate lymphoid cells.. 611. 2022
Common human genetic variants of APOE impact murine COVID-19 mortality.. 611. 2022
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut.. 610. 2022
35 years of channelling potassium ions.. 608. 2022
Prefrontal feature representations drive memory recall.. 608. 2022
ZBTB46 defines and regulates ILC3s that protect the intestine.. 609. 2022
Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.. 606. 2022
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.. 607. 2022
Fundamental immune-oncogenicity trade-offs define driver mutation fitness.. 606. 2022
CDC7-independent G1/S transition revealed by targeted protein degradation.. 605. 2022
TLR7 gain-of-function genetic variation causes human lupus.. 605. 2022
Programme of self-reactive innate-like T cell-mediated cancer immunity.. 605. 2022
Rare coding variants in ten genes confer substantial risk for schizophrenia.. 604. 2022
Brain charts for the human lifespan.. 604. 2022
Anatomic position determines oncogenic specificity in melanoma.. 604. 2022
N⁶-methyladenosine in poly(A) tails stabilize VSG transcripts.. 604. 2022
Human gut bacteria produce Τ_Η17-modulating bile acid metabolites.. 603. 2022
Immune regulation by fungal strain diversity in inflammatory bowel disease.. 603. 2022
Broadly neutralizing antibodies target a haemagglutinin anchor epitope.. 602. 2021
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation.. 600. 2021
An autoimmune stem-like CD8 T cell population drives type 1 diabetes.. 602. 2021
The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.. 600. 2021
Diverse alterations associated with resistance to KRAS(G12C) inhibition.. 599. 2021
Disruption of mitochondrial complex I induces progressive parkinsonism.. 599. 2021
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.. 599. 2021
Dietary fructose improves intestinal cell survival and nutrient absorption.. 597. 2021
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers.. 596. 2021
Phase separation drives aberrant chromatin looping and cancer development.. 595. 2021
Localization atomic force microscopy.. 594. 2021
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.. 595. 2021
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection.. 595. 2021
Reconstruction of ancient microbial genomes from the human gut.. 594. 2021
Thymic development of gut-microbiota-specific T cells.. 594. 2021
A molecular single-cell lung atlas of lethal COVID-19.. 595. 2021
The spatial landscape of lung pathology during COVID-19 progression.. 593. 2021
The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.. 592. 2021
Multi-kingdom ecological drivers of microbiota assembly in preterm infants.. 591. 2021
Glutamate transporters have a chloride channel with two hydrophobic gates.. 591. 2021
CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.. 591. 2021
A gene-environment-induced epigenetic program initiates tumorigenesis.. 590. 2021
Evolution of antibody immunity to SARS-CoV-2.. 591. 2021
H1 histones control the epigenetic landscape by local chromatin compaction.. 589. 2020
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.. 589. 2020
The gut microbiota is associated with immune cell dynamics in humans.. 588. 2020
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.. 589. 2020
Parallel ascending spinal pathways for affective touch and pain.. 587. 2020
Single-cell mutation analysis of clonal evolution in myeloid malignancies.. 587. 2020
Cancer immunotherapy via targeted TGF-β signalling blockade in T_H cells.. 587. 2020
TGF-β suppresses type 2 immunity to cancer.. 587. 2020
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.. 586. 2020
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.. 585. 2020
Age-induced accumulation of methylmalonic acid promotes tumour progression.. 585. 2020
Histone H3.3 phosphorylation amplifies stimulation-induced transcription.. 583. 2020
A metabolic pathway for bile acid dehydroxylation by the gut microbiome.. 582. 2020
Senolytic CAR T cells reverse senescence-associated pathologies.. 583. 2020
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.. 581. 2020
Notch signalling drives synovial fibroblast identity and arthritis pathology.. 582. 2020
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells.. 581. 2020
Centrosome anchoring regulates progenitor properties and cortical formation.. 580. 2020
Ball-and-chain inactivation in a calcium-gated potassium channel.. 580. 2020
Author Correction: Bile acid metabolites control T_H17 and T_reg cell differentiation.. 579. 2020
Author Correction: Quantifying secondary transport at single-molecule resolution.. 579. 2020
Global chemical effects of the microbiome include new bile-acid conjugations.. 579. 2020
Sex-specific adipose tissue imprinting of regulatory T cells.. 579. 2020
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.. 579. 2020
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.. 578. 2020
Genomic basis for RNA alterations in cancer.. 578. 2020
Pan-cancer analysis of whole genomes.. 578. 2020
Patterns of somatic structural variation in human cancer genomes.. 578. 2020
Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation.. 578. 2020
Tobacco smoking and somatic mutations in human bronchial epithelium.. 578. 2020
Mechanism of adrenergic Ca_V1.2 stimulation revealed by proximity proteomics.. 577. 2020
Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice.. 577. 2020
Author Correction: Tumour lineage shapes BRCA-mediated phenotypes.. 577. 2020
Five 'power skills' for becoming a team leader.. 577. 2020
Impaired cell fate through gain-of-function mutations in a chromatin reader.. 577. 2019
Bile acid metabolites control T_H17 and T_reg cell differentiation.. 576. 2019
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.. 575. 2019
Quantifying secondary transport at single-molecule resolution.. 575. 2019
Dietary salt promotes cognitive impairment through tau phosphorylation.. 574. 2019
The microbiota regulate neuronal function and fear extinction learning.. 574. 2019
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.. 574. 2019
α-Ketoglutarate links p53 to cell fate during tumour suppression.. 573. 2019
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.. 573. 2019
Force-induced conformational changes in PIEZO1.. 573. 2019
Tumour lineage shapes BRCA-mediated phenotypes.. 571. 2019
m⁶A enhances the phase separation potential of mRNA.. 571. 2019
Somatic mutations and cell identity linked by Genotyping of Transcriptomes.. 571. 2019
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.. 571. 2019
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.. 571. 2019
TOX is a critical regulator of tumour-specific T cell differentiation.. 571. 2019
Distinct fibroblast subsets drive inflammation and damage in arthritis.. 570. 2019
Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia.. 569. 2019
Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors.. 569. 2019
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.. 568. 2019
Nitrosative stress drives heart failure with preserved ejection fraction.. 568. 2019
The bone marrow microenvironment at single-cell resolution.. 569. 2019
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.. 568. 2019
Why you need a support team.. 568. 2019
Efficacy of MEK inhibition in patients with histiocytic neoplasms.. 567. 2019
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.. 567. 2019
Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling.. 567. 2019
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.. 567. 2019
Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers.. 566. 2019
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.. 565. 2019
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.. 565. 2019
Helios is a key transcriptional regulator of outer hair cell maturation.. 563. 2018
Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir.. 563. 2018
Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.. 563. 2018
Publisher Correction: The effect of hydration number on the interfacial transport of sodium ions.. 563. 2018
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.. 562. 2018
Combination therapy with anti-HIV-1 antibodies maintains viral suppression.. 561. 2018
Discovery of a periosteal stem cell mediating intramembranous bone formation.. 562. 2018
Evidence that CD32a does not mark the HIV-1 latent reservoir.. 561. 2018
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia.. 561. 2018
Author Correction: Hypothalamic stem cells control ageing speed partly through exosomal miRNAs.. 560. 2018
Author Correction: Pancreas regeneration.. 560. 2018
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.. 560. 2018
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.. 560. 2018
EMI1 switches from being a substrate to an inhibitor of APC/C^CDH1 to start the cell cycle.. 558. 2018
Genomic atlas of the human plasma proteome.. 558. 2018
The effect of hydration number on the interfacial transport of sodium ions.. 557. 2018
DNA methylation-based classification of central nervous system tumours.. 555. 2018
HER kinase inhibition in patients with HER2- and HER3-mutant cancers.. 554. 2018
Chromosomal instability drives metastasis through a cytosolic DNA response.. 553. 2018
High response rate to PD-1 blockade in desmoplastic melanomas.. 553. 2018
Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.. 553. 2018
Senescence-associated reprogramming promotes cancer stemness.. 553. 2017
Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.. 551. 2017
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy.. 551. 2017
Dynamics of P-type ATPase transport revealed by single-molecule FRET.. 551. 2017
Four ethical priorities for neurotechnologies and AI.. 551. 2017
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.. 551. 2017
Association analysis identifies 65 new breast cancer risk loci.. 551. 2017
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.. 551. 2017
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.. 549. 2017
Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet.. 550. 2017
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.. 549. 2017
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.. 549. 2017
Competing memories of mitogen and p53 signalling control cell-cycle entry.. 549. 2017
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.. 549. 2017
Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.. 548. 2017
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.. 549. 2017
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.. 548. 2017
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.. 548. 2017
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs.. 548. 2017
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.. 547. 2017
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.. 547. 2017
Fischer et al. reply.. 547. 2017
Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.. 546. 2017
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.. 546. 2017
Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation.. 547. 2017
Stability and function of regulatory T cells expressing the transcription factor T-bet.. 546. 2017
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.. 546. 2017
Chromatin states define tumour-specific T cell dysfunction and reprogramming.. 545. 2017
Conversion of adult endothelium to immunocompetent haematopoietic stem cells.. 545. 2017
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.. 545. 2017
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.. 543. 2017
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.. 543. 2017
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.. 542. 2017
Integrated genomic characterization of oesophageal carcinoma.. 541. 2017
Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability.. 541. 2016
m⁶A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination.. 540. 2016
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs.. 539. 2016
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.. 539. 2016
The epichaperome is an integrated chaperome network that facilitates tumour survival.. 538. 2016
Autocrine BDNF-TrkB signalling within a single dendritic spine.. 538. 2016
Perspective: What next for treatment?. 537. 2016
Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells.. 539. 2016
m(6)A RNA methylation promotes XIST-mediated transcriptional repression.. 537. 2016
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.. 537. 2016
An integrated design and fabrication strategy for entirely soft, autonomous robots.. 536. 2016
Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis.. 538. 2016
Physiology: Stressed-out chromatin promotes longevity.. 534. 2016
A combinatorial strategy for treating KRAS-mutant lung cancer.. 534. 2016
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.. 535. 2016
Co-repressor CBFA2T2 regulates pluripotency and germline development.. 534. 2016
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.. 533. 2016
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.. 534. 2016
Age-dependent modulation of vascular niches for haematopoietic stem cells.. 532. 2016
Distinct bone marrow blood vessels differentially regulate haematopoiesis.. 532. 2016
Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism.. 531. 2016
Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.. 535. 2016
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.. 536. 2016
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.. 531. 2016
Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.. 534. 2016
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.. 531. 2016
Corrigendum: Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis.. 533. 2016
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.. 530. 2016
Divergent clonal selection dominates medulloblastoma at recurrence.. 529. 2016
The histone chaperone CAF-1 safeguards somatic cell identity.. 528. 2015
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.. 528. 2015
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.. 528. 2015
Immune homeostasis enforced by co-localized effector and regulatory T cells.. 528. 2015
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.. 527. 2015
Tumour exosome integrins determine organotropic metastasis.. 527. 2015
Mutations driving CLL and their evolution in progression and relapse.. 526. 2015
Oxidative stress inhibits distant metastasis by human melanoma cells.. 527. 2015
Dynamic m(6)A mRNA methylation directs translational control of heat shock response.. 526. 2015
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.. 526. 2015
Projections from neocortex mediate top-down control of memory retrieval.. 526. 2015
A global reference for human genetic variation.. 526. 2015
An integrated map of structural variation in 2,504 human genomes.. 526. 2015
BET inhibitor resistance emerges from leukaemia stem cells.. 525. 2015
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.. 525. 2015
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.. 526. 2015
Cell biology: Countercurrents in lipid flow.. 525. 2015
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.. 525. 2015
SEC14L2 enables pan-genotype HCV replication in cell culture.. 524. 2015
Conformational dynamics of a class C G-protein-coupled receptor.. 524. 2015
Comprehensive genomic profiles of small cell lung cancer.. 524. 2015
Hippocampal-prefrontal input supports spatial encoding in working memory.. 522. 2015
Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling.. 522. 2015
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.. 522. 2015
Therapy-induced tumour secretomes promote resistance and tumour progression.. 520. 2015
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.. 521. 2015
Transport domain unlocking sets the uptake rate of an aspartate transporter.. 518. 2015
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.. 519. 2014
Cancer: Antitumour immunity gets a boost.. 515. 2014
Open access is tiring out peer reviewers.. 515. 2014
A comparative encyclopedia of DNA elements in the mouse genome.. 515. 2014
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.. 518. 2014
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.. 517. 2014
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.. 517. 2014
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.. 514. 2014
Rb suppresses human cone-precursor-derived retinoblastoma tumours.. 514. 2014
Gibbon genome and the fast karyotype evolution of small apes.. 513. 2014
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.. 515. 2014
Piezo1 integration of vascular architecture with physiological force.. 515. 2014
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.. 513. 2014
Comprehensive molecular characterization of gastric adenocarcinoma.. 513. 2014
Comprehensive molecular profiling of lung adenocarcinoma.. 511. 2014
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.. 511. 2014
Hepatitis C: Treatment triumphs.. 510. 2014
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.. 511. 2014
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.. 508. 2014
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.. 509. 2014
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.. 507. 2014
A transcriptional switch underlies commitment to sexual development in malaria parasites.. 507. 2014
Comprehensive molecular characterization of urothelial bladder carcinoma.. 507. 2014
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.. 506. 2014
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.. 505. 2013
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.. 505. 2013
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.. 504. 2013
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.. 504. 2013
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.. 502. 2013
MX2 is an interferon-induced inhibitor of HIV-1 infection.. 502. 2013
Perspective: Graduation time.. 502. 2013
DNMT1-interacting RNAs block gene-specific DNA methylation.. 503. 2013
Paneth cells as a site of origin for intestinal inflammation.. 503. 2013
Completion of the entire hepatitis C virus life cycle in genetically humanized mice.. 501. 2013
A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.. 500. 2013
Perspective: combined forces.. 498. 2013
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.. 500. 2013
Comprehensive molecular characterization of clear cell renal cell carcinoma.. 499. 2013
Transport dynamics in a glutamate transporter homologue.. 502. 2013
Mutational heterogeneity in cancer and the search for new cancer-associated genes.. 499. 2013
Control of angiogenesis by AIBP-mediated cholesterol efflux.. 498. 2013
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.. 498. 2013
High-level semi-synthetic production of the potent antimalarial artemisinin.. 496. 2013
Structural and molecular interrogation of intact biological systems.. 497. 2013
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.. 496. 2013
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.. 496. 2013
Distinct extended amygdala circuits for divergent motivational states.. 496. 2013
Porous materials with optimal adsorption thermodynamics and kinetics for CO2 separation.. 495. 2013
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.. 495. 2013
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.. 494. 2013
Novel Foxo1-dependent transcriptional programs control T(reg) cell function.. 491. 2012
An integrated map of genetic variation from 1,092 human genomes.. 491. 2012
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.. 491. 2012
Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter.. 491. 2012
Comprehensive genomic characterization of squamous cell lung cancers.. 489. 2012
Initiation of transcription-coupled repair characterized at single-molecule resolution.. 490. 2012
An integrated encyclopedia of DNA elements in the human genome.. 489. 2012
Architecture of the human regulatory network derived from ENCODE data.. 489. 2012
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.. 489. 2012
Landscape of transcription in human cells.. 489. 2012
Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.. 488. 2012
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.. 488. 2012
Passenger deletions generate therapeutic vulnerabilities in cancer.. 488. 2012
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.. 487. 2012
Comprehensive molecular characterization of human colon and rectal cancer.. 487. 2012
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.. 486. 2012
α2δ expression sets presynaptic calcium channel abundance and release probability.. 486. 2012
Melanoma genome sequencing reveals frequent PREX2 mutations.. 485. 2012
Restoration of vision after transplantation of photoreceptors.. 485. 2012
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.. 483. 2012
Insights into hominid evolution from the gorilla genome sequence.. 483. 2012
IDH mutation impairs histone demethylation and results in a block to cell differentiation.. 483. 2012
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.. 483. 2012
Extrathymically generated regulatory T cells control mucosal TH2 inflammation.. 482. 2012
Science funding: Provocative questions in cancer research.. 481. 2012
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.. 481. 2012
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).. 480. 2011
Neuronal filtering of multiplexed odour representations.. 479. 2011
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.. 480. 2011
A high-resolution map of human evolutionary constraint using 29 mammals.. 478. 2011
ATP-induced helicase slippage reveals highly coordinated subunits.. 478. 2011
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.. 478. 2011
Human metabolic individuality in biomedical and pharmaceutical research.. 477. 2011
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.. 477. 2011
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.. 475. 2011
Integrated genomic analyses of ovarian carcinoma.. 474. 2011
A genetically humanized mouse model for hepatitis C virus infection.. 474. 2011
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.. 474. 2011
Perspective: miles to go before we sleep.. 474. 2011
Perspective: test and treat this silent killer.. 474. 2011
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.. 474. 2011
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.. 473. 2011
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.. 473. 2011
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.. 474. 2011
A diverse range of gene products are effectors of the type I interferon antiviral response.. 472. 2011
Neuronal activity is required for the development of specific cortical interneuron subtypes.. 472. 2011
A cis-regulatory map of the Drosophila genome.. 471. 2011
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.. 471. 2011
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.. 471. 2011
Inactivating mutations of acetyltransferase genes in B-cell lymphoma.. 471. 2011
Amygdala circuitry mediating reversible and bidirectional control of anxiety.. 471. 2011
The genomic complexity of primary human prostate cancer.. 470. 2011
Mapping copy number variation by population-scale genome sequencing.. 470. 2011
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.. 470. 2011
Comparative and demographic analysis of orang-utan genomes.. 469. 2011
Save university arts from the bean counters.. 468. 2010
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.. 469. 2010
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.. 469. 2010
Glioblastoma stem-like cells give rise to tumour endothelium.. 468. 2010
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.. 468. 2010
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration.. 468. 2010
Suppression of inflammation by a synthetic histone mimic.. 468. 2010
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.. 468. 2010
A map of human genome variation from population-scale sequencing.. 467. 2010
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.. 467. 2010
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.. 467. 2010
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.. 467. 2010
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.. 467. 2010
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.. 467. 2010
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.. 466. 2010
Sparse coding and high-order correlations in fine-scale cortical networks.. 466. 2010
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.. 465. 2010
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.. 465. 2010
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.. 465. 2010
Single-molecule dynamics of gating in a neurotransmitter transporter homologue.. 465. 2010
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.. 465. 2010
Migrastatin analogues target fascin to block tumour metastasis.. 464. 2010
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.. 464. 2010
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.. 464. 2010
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.. 464. 2010
Active site remodelling accompanies thioester bond formation in the SUMO E1.. 463. 2010
The landscape of somatic copy-number alteration across human cancers.. 463. 2010
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.. 463. 2010
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.. 462. 2009
Transport mechanism of a bacterial homologue of glutamate transporters.. 462. 2009
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.. 461. 2009
Inhibitors selective for mycobacterial versus human proteasomes.. 461. 2009
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.. 461. 2009
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells.. 460. 2009
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.. 460. 2009
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.. 459. 2009
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.. 459. 2009
CBP/p300-mediated acetylation of histone H3 on lysine 56.. 459. 2009
Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation.. 458. 2009
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.. 458. 2009
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.. 457. 2009
BAX activation is initiated at a novel interaction site.. 455. 2008
Somatic mutations affect key pathways in lung adenocarcinoma.. 455. 2008
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.. 455. 2008
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.. 456. 2008
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.. 455. 2008
Comprehensive genomic characterization defines human glioblastoma genes and core pathways.. 455. 2008
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.. 455. 2008
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.. 455. 2008
A biophysicist marvels at the idea of grabbing microscopic particles with light by tweaking its phase.. 454. 2008
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.. 454. 2008
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.. 453. 2008
Clathrin is a key regulator of basolateral polarity.. 452. 2008
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.. 453. 2008
TRPC channel activation by extracellular thioredoxin.. 451. 2008
Reprogramming of human somatic cells to pluripotency with defined factors.. 451. 2007
Intrinsic motions along an enzymatic reaction trajectory.. 450. 2007
Characterizing the cancer genome in lung adenocarcinoma.. 450. 2007
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.. 449. 2007
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.. 449. 2007
LKB1 modulates lung cancer differentiation and metastasis.. 448. 2007
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.. 447. 2007
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.. 447. 2007
Keeping faith with trial volunteers.. 446. 2007
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.. 446. 2007
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.. 446. 2007
Fish can infer social rank by observation alone.. 445. 2007
Restoration of p53 function leads to tumour regression in vivo.. 445. 2007
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.. 445. 2007
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.. 445. 2007
Foxp3-dependent programme of regulatory T-cell differentiation.. 445. 2007
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis.. 444. 2006
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.. 442. 2006
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.. 442. 2006
Identification of a tumour suppressor network opposing nuclear Akt function.. 441. 2006
Lysyl oxidase is essential for hypoxia-induced metastasis.. 440. 2006
Toll-dependent selection of microbial antigens for presentation by dendritic cells.. 440. 2006
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.. 438. 2005
BRAF mutation predicts sensitivity to MEK inhibition.. 439. 2005
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion.. 438. 2005
Local translation of RhoA regulates growth cone collapse.. 436. 2005
RNA interference is an antiviral defence mechanism in Caenorhabditis elegans.. 436. 2005
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.. 436. 2005
Genome sequencing in microfabricated high-density picolitre reactors.. 437. 2005
Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis.. 436. 2005
Dynamics of chronic myeloid leukaemia.. 435. 2005
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase.. 435. 2005
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.. 434. 2005
Pax3 functions at a nodal point in melanocyte stem cell differentiation.. 433. 2005
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction.. 433. 2005
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.. 433. 2005
Antibiotics at the crossroads.. 431. 2004
Structure of a glutamate transporter homologue from Pyrococcus horikoshii.. 431. 2004
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking.. 431. 2004
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.. 430. 2004
Role of transposable elements in heterochromatin and epigenetic control.. 430. 2004
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.. 430. 2004
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.. 427. 2004
Sortilin is essential for proNGF-induced neuronal cell death.. 427. 2004
Mice cloned from olfactory sensory neurons.. 428. 2004
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.. 425. 2003
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing.. 422. 2003
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.. 422. 2003
Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis.. 421. 2003
Overview of the Alliance for Cellular Signaling.. 420. 2002
A gene expression map of human chromosome 21 orthologues in the mouse.. 420. 2002
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.. 420. 2002
Brain development: memory enhancement in early childhood.. 419. 2002
A biological role for prokaryotic ClC chloride channels.. 419. 2002
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.. 419. 2002
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.. 419. 2002
A physical map of the mouse genome.. 418. 2002
Pluripotency of mesenchymal stem cells derived from adult marrow.. 418. 2002
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.. 416. 2002
AIDS vaccines: on the trail of two trials.. 415. 2002
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.. 414. 2001
Malaria. Cooperative silencing elements in var genes.. 412. 2001
Retinal ganglion cells act largely as independent encoders.. 411. 2001
Neurogenesis in the adult is involved in the formation of trace memories.. 410. 2001
Functional annotation of a full-length mouse cDNA collection.. 409. 2001
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.. 409. 2001
Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum.. 407. 2000
Regenerating the damaged central nervous system.. 407. 2000
Peroxynitrite reductase activity of bacterial peroxiredoxins.. 407. 2000
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.. 406. 2000
Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin.. 406. 2000
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1.. 404. 2000
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.. 403. 2000
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.. 402. 1999
The RCAF complex mediates chromatin assembly during DNA replication and repair.. 402. 1999
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.. 401. 1999
Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima.. 399. 1999
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.. 399. 1999
Calmodulin supports both inactivation and facilitation of L-type calcium channels.. 399. 1999
Cyclosporine induces cancer progression by a cell-autonomous mechanism.. 397. 1999
The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.. 395. 1998
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.. 394. 1998
Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans.. 391. 1998
Role of the histone deacetylase complex in acute promyelocytic leukaemia.. 391. 1998
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.. 391. 1998
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours.. 389. 1997
Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit.. 389. 1997
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.. 389. 1997
Optical detection of a quantal presynaptic membrane turnover.. 388. 1997
Synthesis of epothilones A and B in solid and solution phase.. 387. 1997
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes.. 385. 1997
Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation.. 385. 1997
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.. 384. 1996
The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes.. 383. 1996
Using antibodies to perturb the coordination sphere of a transition metal complex.. 382. 1996
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.. 382. 1996
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.. 381. 1996
Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors.. 380. 1996
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.. 380. 1996
Bax-independent inhibition of apoptosis by Bcl-XL.. 379. 1996
Phosphorylation of Raf by ceramide-activated protein kinase.. 378. 1995
Ca(2+)- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils.. 377. 1995
Specificity in chaperonin-mediated protein folding.. 375. 1995
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.. 374. 1995
CpG motifs in bacterial DNA trigger direct B-cell activation.. 374. 1995
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.. 370. 1994
Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions.. 363. 1993
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide.. 363. 1993
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs.. 359. 1992
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression.. 358. 1992
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.. 358. 1992
Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4.. 357. 1992
Crystalline ribonuclease A loses function below the dynamical transition at 220 K.. 357. 1992
A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion.. 356. 1992
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.. 354. 1991
Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation.. 354. 1991
On the complexity of self.. 353. 1991
Sequence analysis of peptides bound to MHC class II molecules.. 353. 1991
Targeting of transmembrane and GPI-anchored forms of N-CAM to opposite domains of a polarized epithelial cell.. 353. 1991
The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy.. 352. 1991
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.. 350. 1991
PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome.. 349. 1991
Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1.. 348. 1990
Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous.. 347. 1990
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway.. 346. 1990
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis.. 345. 1990
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription.. 344. 1990
Structure and evolution of a human erythroid transcription factor.. 343. 1990
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.. 342. 1989
Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons.. 339. 1989
Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis.. 339. 1989
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting.. 337. 1989
HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides.. 336. 1988
Deactivation of macrophages by transforming growth factor-beta.. 334. 1988
Positron emission tomographic studies of the cortical anatomy of single-word processing.. 331. 1988
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression.. 331. 1988
Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay.. 330. 1987
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene.. 330. 1987
Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion.. 324. 1986
Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity.. 319. 1986
Local cytoplasmic calcium gradients in living mitotic cells.. 316. 1985
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.. 316. 1985
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells.. 315. 1985
A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells.. 313. 1985
Suppression of the normal mouse c-myc oncogene in human lymphoma cells.. 313. 1985
Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis.. 313. 1985
Dynorphin(1-13) improves survival in cats with focal cerebral ischaemia.. 312. 1984
Mitogens increase phosphorylation of phosphoinositides in thymocytes.. 312. 1984
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1.. 310. 1984
Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase.. 310. 1984
Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide.. 309. 1984
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.. 308. 1984
Genetically restricted antigen presentation for immunological tolerance and suppression.. 308. 1984
Hydroxyl radical scavengers inhibit human natural killer cell activity.. 307. 1984
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.. 307. 1984
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.. 305. 1983
RNA viruses. Reverse transcription in plants?. 304. 1983
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious.. 304. 1983
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.. 303. 1983
Only membrane-associated RSV src proteins have amino-terminally bound lipid.. 302. 1983
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.. 300. 1982
Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions.. 299. 1982
De novo methylation and expression of retroviral genomes during mouse embryogenesis.. 298. 1982
Na+ transport and flux ratio through apical Na+ channels in toad bladder.. 297. 1982
Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.. 296. 1982
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.. 295. 1982
Thrombospondin is the endogenous lectin of human platelets.. 295. 1982
Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus.. 289. 1981
Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells.. 287. 1980
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.. 287. 1980
Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein.. 285. 1980
Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.. 283. 1980
Temperature-dependent X-ray diffraction as a probe of protein structural dynamics.. 280. 1979
Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding.. 278. 1979
Association of a B-cell alloantigen with susceptibility to rheumatic fever.. 278. 1979
Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface.. 277. 1979
Evidence for two separate opiate peptide neuronal systems.. 275. 1978
Myasthenia gravis serum reduces acetylcholine sensitivity in cultured rat myotubes.. 267. 1977
Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat.. 265. 1977
Strain-dependent variations in number of midbrain dopaminergic neurones.. 264. 1976
Predicting the course of Gompertzian growth.. 264. 1976
Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell.. 264. 1976
Influence of social setting on the induction of brain cyclic AMP in response to electric shock in the rat.. 263. 1976
Serum containing endotoxin-induced tumour necrosis factor substitutes for helper T cells.. 263. 1976
Crystal structure of elastase-substrate complex at -- 55 degrees C.. 263. 1976
Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia.. 263. 1976
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.. 260. 1976
Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity.. 260. 1976
Nuclease that preferentially inactivates DNA containing mismatched bases.. 258. 1975
Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5 angstrom resolution using amino acid sequence data.. 255. 1975
Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci.. 255. 1975
Membrane protein kinase alteration in Duchenne muscular dystrophy.. 254. 1975
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus.. 253. 1975
Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse.. 253. 1975
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).. 251. 1974
Stimulation of synaptosomal dopamine synthesis by veratridine.. 250. 1974
Muscle membrane protein kinase in myotonic muscular dystrophy.. 250. 1974
Serotonin and pituitary-adrenal function.. 248. 1974
Cholecystokinin elicits satiety in rats with open gastric fistulas.. 245. 1973
Production of antibody to sheep red blood cells by human tonsil cells in vitro.. 243. 1973
The bacterial cell surface.. 234. 1971
Axonal transport of neurotubule protein.. 227. 1970
Multiple antibiotic resistance in a bacterium with suppressed autolytic system.. 227. 1970
Conformation of human serum high density lipoprotein and its peptide components.. 224. 1969
Human serum beta lipoprotein and beta apoprotein.. 223. 1969
Enzymatic synthesis of adrenaline in mammalian brain.. 221. 1969
Delayed hypersensitivity and transplantation immunity elicited by soluble antigens of chemically induced tumours in inbred guinea-pigs.. 220. 1968
Human serum beta-lipoprotein.. 219. 1968
Acute pharmacology of melatonin.. 214. 1967
Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria.. 208. 1965
Effect of inhibition of RNA synthesis on neural information storage.. 207. 1965
EFFECT OF OESTRADIOL ON BONE MARROW TRANSPLANTATION IN LETHALLY IRRADIATED MICE.. 203. 1964
INDIVIDUAL AND SUB-GROUP ANTIGENIC SPECIFICITY OF BENCE-JONES PROTEIN.. 200. 1963
Retinotectal connexions after retinal regeneration.. 196. 1962
Evidence for a new allele in the Kidd blood group system in Indians of northern Mato Grosso, Brazil.. 186. 1960
Increase in 'alkaline' ribonuclease of rat kidney cortex after lysozyme and egg-white administration.. 186. 1960
Formation of malate from glycollate by Pseudomonas ovalis Chester.. 183. 1959
Effect of growth substrates on isocitratase formation by Pseudomonas ovalis Chester.. 182. 1958
How pandemic lockdowns changed workplace friendships. 2023
Tormentor mentors, and how to survive them. 2023
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.. 614. 2023
Author Correction: Patterns of somatic structural variation in human cancer genomes.. 614. 2023
Publisher Correction: Brain charts for the human lifespan.. 610. 2022
Author Correction: Comparative and demographic analysis of orang-utan genomes.. 608. 2022
Author Correction: Immune regulation by fungal strain diversity in inflammatory bowel disease.. 608. 2022
Author Correction: Fundamental immune-oncogenicity trade-offs define driver mutation fitness.. 606. 2022
How and why to say 'no' to colleagues and collaborators. 2022
Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism.. 603. 2022
My lesson from successful scientists: success can be learnt. 2022
Cardiovascular diseases disrupt the bone-marrow niche.. 601. 2022
The United States needs a department of technology and science policy.. 600. 2021
When you recommend someone for an opportunity, follow through. 2021
Author Correction: A molecular single-cell lung atlas of lethal COVID-19.. 598. 2021
Author Correction: Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers.. 598. 2021
Six mentoring tips as we enter year two of COVID. 2021
Five tips for understanding and managing your emotions to build flourishing connections. 2021
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes.. 591. 2021
Author Correction: Sex-specific adipose tissue imprinting of regulatory T cells.. 591. 2021
Linguistic tricks to grab your online audience's attention.. 591. 2021
Five steps for networking during a pandemic. 2020
Author Correction: FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.. 585. 2020
Mentoring during the COVID-19 pandemic. 2020
Put participants first in conference design. 2019
Author Correction: The bone marrow microenvironment at single-cell resolution.. 572. 2019
Networking for introverted scientists. 2019
Three steps to landing an undergraduate research internship.. 565. 2019
Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response.. 525. 2015
Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.. 525. 2015
Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer.. 525. 2015
NIH cancer chief wants more with less: by Meredith Wadman.. 475. 2011
Epidemiology: How common is autism?. 474. 2011
Cancer: mixing cocktails.. 449. 2007
Immunology: Oxygen and the inflammatory cell.. 422. 2003
David Phillips (1924-99).. 399. 1999
HIV vaccines. Back to primary school.. 376. 1995
HIV. Cyclophilins unfold the Gag?. 365. 1993
Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4.. 360. 1992
Cancer. Therapy by photon activation?. 336. 1988
Reverse transcriptase rides again.. 314. 1985
A growing role for reverse transcription.. 299. 1982
A heritable, non-genetic road to cancer evolution. 2022
A stem-cell basis for skeletal ageing. 2021
Psychedelics re-engineered for potential use in the clinic. 2021
An umbrella approach to test lung cancer therapies. 2020
Parkinson's disease grafts benefit from well-timed growth factor. 2020
Risk factor for Alzheimer's disease breaks the blood-brain barrier. 2020
Blood flow forces liver growth. 2018
Epitranscriptomics: Shrinking maps of RNA modifications. 2017
Metastasis: Lymphatic detours for cancer. 2017
Cardiovascular disease: Commonality with cancer. 2017
Regenerative medicine: Interspecies pancreas transplants. 2017
Cancer genomics: Hard-to-reach repairs. 2016
Structural biology: Lipid gymnastics. 2015
HIV: A stamp on the envelope. 2014
Psychology: Good and bad news on the adolescent brain. 2013
Properties of native brain α-synuclein. 2013
Stem cells: Painkillers caught in blood-cell trafficking. 2013
Forum: Immunology: Allergy challenged. 2012
Translational medicine: Primed for resistance. 2012
Stem cells: iPS cells under attack. 2011
Reproductive biology: In vitro sperm maturation. 2011
Drug discovery: How melanomas bypass new therapy. 2010
Cell biology: A sensor for calcium uptake. 2010
Hepatitis C: An unsuspected drug target. 2010
ETS rearrangements and prostate cancer initiation. 2009
Does Rft1 flip an N-glycan lipid precursor? 2008
Arousal by stimulation of deep-brain nuclei. 2008
Cell biology: caught in the traffic. 2007
Biophysics: proteins hunt and gather. 2007
Correspondence patterns: mechanisms and models of human dynamics. 2006
Evolutionary genomics: codon bias and selection on single genomes. 2005
Virology: fresh assault on hepatitis C. 2003
Full circle to cobbled brain. 2002
Vascular biology. Targeted delivery of nitric oxide. 2001
Enzyme evolution. Design by necessity. 2000
HIV. See a pocket, block it. 1999
Quantum enzymology. Tunnel vision. 1999
HIV. Envelope's letters boxed into shape. 1998
Seeking wisdom in innate immunity. 1997
HIV-cell fusion. The viral mousetrap. 1997
Cancer chemotherapy. Heavy metal revival. 1995
Neuropsychology. Modulation by instruction. 1995
Biophysics. The little big bang. 1994
Signal transduction. Fishing in Src-infested waters. 1992
Viral proteases. Molecular metamorphosis. 1991
AIDS. Passive primate protection. 1991
Enzyme evolution. Déjà vu all over again. 1991
Cystic fibrosis. A transport problem? 1990
Resist pseudoscience with respect, not ridicule. 2020
Publishing: Journals, do your own formatting. 2017
MAGI3-AKT3 fusion in breast cancer amended. 2015
Misconduct: don't penalize the honest majority of scientists. 2010
NIH funds support more than a researcher's own lab. 2008
Authors' financial interests should be made known to manuscript reviewers. 2007
Online submission makes authors do all the work. 2005
HIV denialists will exploit any journal's tolerance. 2004
Public-access group supports PubMed Central. 2002
Debt and poverty turn a disease into an epidemic. 2000
A new classification for HIV-1. 1998
US support for malaria research. 1997
The spirit of Dakar: a call for action on malaria. 1997
Redox regulation of cell signalling. 1996
Planning of US AIDS research. 1996
HIV infectivity. 1991
What to call the AIDS virus? 1986
Coronaries and diet. 1984
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus. 1983
Statement on the consideration of biodefence and biosecurity.. 421. 2003
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. 2019
Pancreas regeneration. 2018
Angiocrine functions of organ-specific endothelial cells. 2016
Directional dominance on stature and cognition in diverse human populations. 2015
Genetic studies of body mass index yield new insights for obesity biology. 2015
New genetic loci link adipose and insulin biology to body fat distribution. 2015
The biology of innate lymphoid cells. 2015
Lipid landscapes and pipelines in membrane homeostasis. 2014
Genetics of rheumatoid arthritis contributes to biology and drug discovery. 2013
Chromatin dynamics during cellular reprogramming. 2013
The cancer biomarker problem. 2008
Pathogenesis and therapy of psoriasis. 2007
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. 2006
Role of cholesterol and lipid organization in disease. 2005
Hepatitis C and liver transplantation. 2005
Unravelling hepatitis C virus replication from genome to function. 2005
Regulation of immunity by self-reactive T cells. 2005
Targeted cancer therapy. 2004
For medicinal purposes. 1996
Molecular dynamics simulations in biology. 1990

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