Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Academic Article uri icon

Overview

abstract

  • The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.

publication date

  • January 10, 1980

Research

keywords

  • Endocytosis
  • Hormones
  • alpha-Macroglobulins
  • gamma-Glutamyltransferase

Identity

Scopus Document Identifier

  • 0018864611

Digital Object Identifier (DOI)

  • 10.1038/283162a0

PubMed ID

  • 6153122

Additional Document Info

volume

  • 283

issue

  • 5743