Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein. Academic Article uri icon

Overview

abstract

  • The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.

publication date

  • August 31, 1984

Research

keywords

  • Antibodies, Monoclonal
  • Egg Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • Ovary
  • Ovum
  • Receptors, Cell Surface
  • Zona Pellucida

Identity

Scopus Document Identifier

  • 0021280135

Digital Object Identifier (DOI)

  • 10.1126/science.6474160

PubMed ID

  • 6474160

Additional Document Info

volume

  • 225

issue

  • 4665