The properties of membranes formed from cyclopentanoid analogues of phosphatidylcholine. Academic Article uri icon

Overview

abstract

  • We have examined the thermal characteristics and barrier properties of vesicles formed from six analogues of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). These analogues differ from DPPC in that the glycerol backbone has been replaced by each of the diastereoisomeric cyclopentane-1,2,3-triols. All of these compounds have main gel to liquid-crystal phase transition temperatures within 5 Kelvin of DPPC and four possess comparable enthalpies and entropies of transition. For two of the analogous, however, the values of the enthalpy and entropy of transition are more than double that of DPPC. The permeability characteristics and organization (as measured by diphenylhexatriene fluorescence depolarization) of vesicles formed from these two compounds suggest that their large transition enthalpy and entropy result from either a reorganization of the polar head group region during the transition or interdigitation of the acyl chains of opposing monolayers.

publication date

  • June 10, 1983

Research

keywords

  • Liposomes
  • Pulmonary Surfactants

Identity

Scopus Document Identifier

  • 0021099570

Digital Object Identifier (DOI)

  • 10.1016/0005-2736(83)90030-5

PubMed ID

  • 6687809

Additional Document Info

volume

  • 731

issue

  • 2