Kinetics of spontaneous and plasma-stimulated sphingomyelin transfer. Academic Article uri icon

Overview

abstract

  • The mechanism of transfer of a pyrene-labeled sphingomyelin (PySM) between different lipid compartments was studied by a fluorescence technique. The first-order kinetics are independent of donor and acceptor concentration and the identity of the acceptor; the rates are accelerated by 'structure-breaking' solutes and inhibited by 'structure-making' solutes. These observations are consistent with the transfer of PySM occurring via the aqueous phase that separates the donor and acceptor compartments. We have partially purified a plasma factor that stimulates the transfer rate. Our in vitro results suggest that both spontaneous and stimulated transfer might contribute to the redistribution of sphingomyelin in vivo,

publication date

  • July 20, 1982

Research

keywords

  • Sphingomyelins

Identity

Scopus Document Identifier

  • 0019998166

Digital Object Identifier (DOI)

  • 10.1016/0005-2760(82)90099-6

PubMed ID

  • 6810944

Additional Document Info

volume

  • 712

issue

  • 1