Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies. Academic Article uri icon

Overview

abstract

  • High-resolution gamma camera images of mouse erythroid tumors were obtained by use of leukemia cell-specific monoclonal antibodies labeled with bifunctional radioactive metal chelates. Small tumors (200 to 300 milligrams) were visible without subtraction or enhancement 1 to 5 hours after injection of antibody. Chelate-derivitized monoclonal antibodies permit targeting of a broad spectrum of radioisotopes, including those that are optimum for agamma for gamma camera imaging or positron tomography, as well as those that are tumoricidal.

publication date

  • March 19, 1982

Research

keywords

  • Antibodies, Monoclonal
  • Leukemia, Experimental

Identity

Scopus Document Identifier

  • 0020026251

Digital Object Identifier (DOI)

  • 10.1126/science.7199757

PubMed ID

  • 7199757

Additional Document Info

volume

  • 215

issue

  • 4539