Telomerase activity in normal and malignant hematopoietic cells. Academic Article uri icon

Overview

abstract

  • Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain telomerase activity detectable by a PCR-based assay. Telomerase was also detectable in nonmalignant bone marrow and peripheral blood leukocytes from normal donors, including fractions enriched for granulocytes, T lymphocytes, and monocytes/B cells. Semiquantitative comparison revealed considerable overlap between telomerase activities in samples from normal subjects and leukemia patients, confounding evaluation of the role of telomerase in this disease. These data indicate that human telomerase is not restricted to immortal cells and suggest that the somatic expression of this enzyme may be more widespread than was previously inferred from the decline of human telomeres.

publication date

  • September 26, 1995

Research

keywords

  • Granulocytes
  • Hematopoietic Stem Cells
  • Leukemia
  • Lymphocytes
  • Telomerase

Identity

PubMed Central ID

  • PMC40928

Scopus Document Identifier

  • 0029066169

Digital Object Identifier (DOI)

  • 10.1073/pnas.92.20.9082

PubMed ID

  • 7568077

Additional Document Info

volume

  • 92

issue

  • 20