23Na-NMR study of ion transport across vesicle membranes facilitated by phenylalanine analogs of gramicidin. Academic Article uri icon

Overview

abstract

  • The transport of Na+ ions across phosphatidylcholine/phosphatidylglycerol large unilamellar vesicle membranes facilitated by phenylalanine analogs of gramicidin A has been studied using 23Na-NMR spectroscopy. The four analogs studied were Phe9-, Phe11-, Phe13-and Phe15-gramicidin A. These analogs were found to transport Na+ ions in the following order Phe15 > Phe13 > Phe11 > Phe9. The entropy and enthalpy of activation for the transport of Na+ ions were determined for each analog. A correlation is made between the activation enthalpies and the single channel conductance values of the analogs.

publication date

  • March 14, 1993

Research

keywords

  • Gramicidin
  • Phenylalanine
  • Sodium

Identity

Scopus Document Identifier

  • 0027916206

Digital Object Identifier (DOI)

  • 10.1016/0005-2736(93)90355-4

PubMed ID

  • 7680900

Additional Document Info

volume

  • 1146

issue

  • 2