Impaired interleukin 12 production in human immunodeficiency virus-infected patients. Academic Article uri icon

Overview

abstract

  • Peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-infected patients, asymptomatic or with acquired immunodeficiency virus, produced 10-fold less interleukin 12 (IL-12) free heavy chain and fivefold less biologically active IL-12 heterodimer than PBMC from uninfected healthy donors when challenged in vitro with the common human pathogen Staphylococcus aureus. In contrast, PBMC from HIV-infected individuals and uninfected control donors produced similar levels of tumor necrosis factor alpha, IL-1 beta, and IL-10, and PBMC from HIV-infected individuals produced three- to fourfold more IL-6 compared with PBMC from uninfected control donors. The defect in IL-12 production is not due to hyperproduction of IL-10, a cytokine exerting an autocrine-negative feedback on IL-12 production, but was directly related to HIV infection, as suggested by the reduced ability of monocytes infected in vitro with HIV to produce IL-12. IL-12 deficiency may be an important component of the immunodeficiency associated with HIV infection.

publication date

  • April 1, 1994

Research

keywords

  • HIV Infections
  • Interleukins

Identity

PubMed Central ID

  • PMC2191451

Scopus Document Identifier

  • 0028262475

Digital Object Identifier (DOI)

  • 10.1084/jem.179.4.1361

PubMed ID

  • 7908324

Additional Document Info

volume

  • 179

issue

  • 4