Retinoic acid and homeobox gene regulation. Review uri icon

Overview

abstract

  • Hox genes have been shown to be important regulators of pattern formation in vertebrates. Retinoic acid has been shown to affect the expression of Hox genes in vitro and in vivo, and some of its effects on development correspond to changes in Hox gene expression. The idea that retinoic acid is not simply a powerful pharmocological agent, but rather that it plays an important role in creating the normal expression patterns of Hox genes, is provided by the recent identification of retinoic acid responsive enhancers near Hox genes.

publication date

  • August 1, 1994

Research

keywords

  • Embryonic Induction
  • Gene Expression Regulation, Developmental
  • Genes, Homeobox
  • Tretinoin

Identity

Scopus Document Identifier

  • 0028095534

Digital Object Identifier (DOI)

  • 10.1016/0959-437x(94)90071-a

PubMed ID

  • 7950323

Additional Document Info

volume

  • 4

issue

  • 4