Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Academic Article uri icon

Overview

abstract

  • The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.

publication date

  • October 29, 1993

Research

keywords

  • Lymphoma, Large B-Cell, Diffuse
  • Proto-Oncogenes
  • Zinc Fingers

Identity

Scopus Document Identifier

  • 0027495491

Digital Object Identifier (DOI)

  • 10.1126/science.8235596

PubMed ID

  • 8235596

Additional Document Info

volume

  • 262

issue

  • 5134