Serum levels of GM-CSF are elevated in patients with thrombocytopenia. Academic Article uri icon

Overview

abstract

  • Serum levels of GM-CSF, IL-3 and IL-6 were measured in patients with immune thrombocytopenia (ITP), non-immune thrombocytopenia (NIT), autoimmune haemolytic anaemia (AIHA) and neutropenia. 8/10 children with ITP had elevated serum levels of GM-CSF (mean 18.4 pg/ml) while thrombocytopenic, but only two had detectable levels (mean 4.5 pg/ml) after normalization of the platelet count. In patients with NIT a significant inverse correlation between platelet count and serum levels of GM-CSF was observed. IL-3 and IL-6 levels were not significantly elevated in thrombocytopenic patients and only two of the nine patients with either AIHA or neutropenia had detectable levels of GM-CSF. Thus, GM-CSF may play a role in the response of severe thrombocytopenia.

publication date

  • February 1, 1996

Research

keywords

  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Thrombocytopenia

Identity

Scopus Document Identifier

  • 0030053526

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.1996.d01-1464.x

PubMed ID

  • 8603021

Additional Document Info

volume

  • 92

issue

  • 2