Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain. Academic Article uri icon

Overview

abstract

  • Recently, a family of nuclear co-repressor proteins (TRACs) have been identified that interact with thyroid hormone (TR) and retinoic acid receptors to mediate ligand-independent repression of gene transcription. In this report, we have cloned and characterized a human TRAC, which when expressed as a truncated protein lacking its repressing domains, can abolish endogenous cellular TRAC activity. Use of this inhibitor has uncovered a differential function of TRACs on negative versus positive thyroid hormone response elements and has demonstrated the importance of the TR A/B domain in modulating TRAC function. Thus, isoform-specific functions of the TR may be mediated by their functional interaction with co-repressor proteins.

publication date

  • November 8, 1996

Research

keywords

  • Enhancer Elements, Genetic
  • Receptors, Thyroid Hormone
  • Repressor Proteins

Identity

Scopus Document Identifier

  • 0029855771

Digital Object Identifier (DOI)

  • 10.1074/jbc.271.45.28516

PubMed ID

  • 8910480

Additional Document Info

volume

  • 271

issue

  • 45