Spinal gabapentin is antinociceptive in the rat formalin test. Academic Article uri icon

Overview

abstract

  • Gabapentin is a novel anticonvulsant that may be of value for the relief of clinical pain. To determine whether gabapentin is antinociceptive after spinal administration, the drug was given via an intrathecal catheter in doses from 6 to 200 micrograms/rat 10 min prior to intraplantar formalin. Five percent formalin injected subcutaneously in the right hind paw produced a biphasic reaction consisting of flinching and licking behaviors (phase 1, 0-10 min; phase 2, 10-60 min). Gabapentin dose-dependently reduced the numbers of flinches and the duration of licking during phase 2 of the formalin test. The highest dose of gabapentin (200 micrograms/rat) did not affect the tail-flick response. These results demonstrate that spinal gabapentin is antinociceptive in the formalin test.

publication date

  • January 24, 1997

Research

keywords

  • Acetates
  • Amines
  • Anticonvulsants
  • Cyclohexanecarboxylic Acids
  • Pain
  • gamma-Aminobutyric Acid

Identity

Scopus Document Identifier

  • 0031020305

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(97)13331-6

PubMed ID

  • 9121725

Additional Document Info

volume

  • 222

issue

  • 1