Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue. Academic Article uri icon

Overview

abstract

  • The recently developed technique of gradient, high-resolution magic-angle spinning NMR (g-hr-MAS-NMR) spectroscopy was applied to the study of ex vivo human lipoma and liposarcoma tissue. Compared with conventional 1H-NMR, the g-hr-MAS method yielded a large improvement in spectral resolution and permitted the detection of metabolite resonance's in a well-differentiated liposarcoma that was not observed in spectra of similar samples obtained using nonspinning NMR methods. These findings suggest that g-hr-MAS-NMR spectroscopy provides a key improvement in spectral quality for ex vivo lipoma and liposarcoma tissue thereby permitting a more precise determination of tissue metabolite composition than conventional nonspinning NMR methods.

publication date

  • September 1, 1997

Research

keywords

  • Adipocytes
  • Lipids
  • Magnetic Resonance Spectroscopy
  • Neoplasms, Adipose Tissue

Identity

Scopus Document Identifier

  • 0030884710

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910380307

PubMed ID

  • 9339440

Additional Document Info

volume

  • 38

issue

  • 3