Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Academic Article uri icon

Overview

abstract

  • Neuroplasticity serves an important role for normal striatal function and in disease states. One route to neuroplasticity involves activation of the transcription factor cyclic 3', 5'-adenosine monophosphate (cyclic AMP) response element binding protein (CREB) by phosphorylation of the amino acid 133Ser. Dopamine and glutamate, the two predominant neurotransmitters in the striatum, induce CREB phosphorylation in primary cultures of rat striatum through cyclic AMP and Ca2+ pathways. Here we present the role of N-methyl-D-aspartate receptors and Ca2+ in cyclic AMP-mediated CREB phosphorylation.

publication date

  • January 1, 1998

Research

keywords

  • Corpus Striatum
  • Cyclic AMP
  • Neuronal Plasticity

Identity

PubMed Central ID

  • PMC4205584

Scopus Document Identifier

  • 0031873794

Digital Object Identifier (DOI)

  • 10.1159/000017314

PubMed ID

  • 9691194

Additional Document Info

volume

  • 20

issue

  • 2-3