Rajadhyaksha, Anjali M

Publications

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selected publications

L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development. Channels (Austin, Tex.). 2023 Review GET IT
Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships. Nature communications. 2023 Academic Article GET IT
Ca_v1.3 L-type Ca²⁺ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference. Neuropharmacology. 2022 Academic Article GET IT
Sex differences in the medial prefrontal cortical glutamate system. Biology of sex differences. 2022 Academic Article GET IT
Times cited: 1
Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors. JCI insight. 2021 Academic Article GET IT
Times cited: 4
Dual-process brain mitochondria isolation preserves function and clarifies protein composition. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 5
Loss of Cav1.2 channels impairs hippocampal theta burst stimulation-induced long-term potentiation. Channels (Austin, Tex.). 2020 Academic Article GET IT
Times cited: 4
Correction: Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca²⁺ channels. Molecular psychiatry. 2020 Article GET IT
A Machine Learning Approach to Predicting Autism Risk Genes: Validation of Known Genes and Discovery of New Candidates. Frontiers in genetics. 2020 Academic Article GET IT
Times cited: 259
Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes. Blood. 2020 Academic Article GET IT
Times cited: 14
Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress. Molecular psychiatry. 2020 Academic Article GET IT
Times cited: 7
Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice. Science advances. 2020 Academic Article GET IT
Times cited: 14
SorCS2 is required for social memory and trafficking of the NMDA receptor. Molecular psychiatry. 2020 Academic Article GET IT
Times cited: 11
Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Ca_v1.2 channels in extinction of cocaine conditioned place preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2020 Academic Article GET IT
Times cited: 7
Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca²⁺ channels. Molecular psychiatry. 2019 Academic Article GET IT
Times cited: 10
Anxiety, the chicken or the egg of addiction: targeting G9a for the treatment of comorbid anxiety and cocaine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019 Comment GET IT
Times cited: 1
The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 Academic Article GET IT
Times cited: 21
Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 Academic Article GET IT
Times cited: 23
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 25
Correction: D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome. PloS one. 2018 Academic Article GET IT
Extinction of Contextual Cocaine Memories Requires Ca_v1.2 within D1R-Expressing Cells and Recruits Hippocampal Ca_v1.2-Dependent Signaling Mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Academic Article GET IT
Times cited: 26
D-cycloserine improves synaptic transmission in an animal model of Rett syndrome. PloS one. 2017 Academic Article GET IT
Times cited: 4
From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2017 Review GET IT
Times cited: 76
Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α. Molecular psychiatry. 2017 Academic Article GET IT
Times cited: 62
Altered reward sensitivity in female offspring of cocaine-exposed fathers. Behavioural brain research. 2017 Academic Article GET IT
Times cited: 26
Genetic dissociation of morphine analgesia from hyperalgesia in mice. Psychopharmacology. 2017 Academic Article GET IT
Times cited: 18
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 48
Ca_v1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway. Neurobiology of stress. 2017 Academic Article GET IT
Times cited: 485
Enhancing VTA Ca_v1.3 L-type Ca²⁺ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular psychiatry. 2017 Academic Article GET IT
Times cited: 38
Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Academic Article GET IT
Times cited: 35
Cacna1c: Protecting young hippocampal neurons in the adult brain. Neurogenesis (Austin, Tex.). 2016 Academic Article GET IT
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 55
Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord. Neuron. 2016 Academic Article GET IT
Times cited: 27
L-type Ca²⁺ channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes. The Journal of physiology. 2016 Review GET IT
Times cited: 49
Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability. Neurobiology of disease. 2016 Academic Article GET IT
Times cited: 66
The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons. eNeuro. 2016 Academic Article GET IT
Times cited: 44
Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area. Journal of neurophysiology. 2014 Academic Article GET IT
Times cited: 48
Lack of association between autism and anti-GM1 ganglioside antibody. Neurology. 2013 Academic Article GET IT
Times cited: 9
Autism and Lyme disease--reply. JAMA. 2013 Letter GET IT
Times cited: 1
Stereotaxic microinjection of viral vectors expressing Cre recombinase to study the role of target genes in cocaine conditioned place preference. Journal of visualized experiments : JoVE. 2013 Academic Article GET IT
Times cited: 3
Markers of Celiac Disease and Gluten Sensitivity in Children with Autism. PloS one. 2013 Academic Article GET IT
Times cited: 78
Serologic markers of Lyme disease in children with autism. JAMA. 2013 Academic Article GET IT
Times cited: 6
Selective genetic deletion of cacna1c in the mouse prefrontal cortex. Molecular psychiatry. 2012 Academic Article GET IT
Times cited: 8
Forebrain elimination of cacna1c mediates anxiety-like behavior in mice. Molecular psychiatry. 2012 Letter GET IT
Times cited: 62
Brain-derived neurotrophic factor genotype impacts the prenatal cocaine-induced mouse phenotype. Developmental neuroscience. 2012 Academic Article GET IT
Times cited: 13
Cav 1.3 L-type Ca ( 2+) channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure. Channels (Austin, Tex.). 2012 Academic Article GET IT
Times cited: 12
Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry. 2011 Academic Article GET IT
Times cited: 8
Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behavioural brain research. 2011 Academic Article GET IT
Times cited: 34
Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 70
Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 48
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. American journal of human genetics. 2010 Academic Article GET IT
Times cited: 73
Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference. Neuropharmacology. 2010 Academic Article GET IT
Times cited: 10
Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5. Neuroscience. 2010 Academic Article GET IT
Times cited: 5
Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence. Journal of neurogenetics. 2010 Academic Article GET IT
Times cited: 38
Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference. Neuroscience letters. 2009 Academic Article GET IT
Times cited: 3
Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance. The Journal of pharmacology and experimental therapeutics. 2008 Academic Article GET IT
Times cited: 14
Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Journal of neurochemistry. 2008 Academic Article GET IT
Times cited: 68
Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics. 2008 Academic Article GET IT
Times cited: 58
NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking. Psychopharmacology. 2007 Academic Article GET IT
Times cited: 61
Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels. Journal of neurochemistry. 2006 Academic Article GET IT
Times cited: 39
Psychostimulants, L-type calcium channels, kinases, and phosphatases. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2005 Review GET IT
Times cited: 28
Psychostimulants, Protein phosphorylation and Gene expression: a growing role of L-type calcium channels. Cellscience. 2005 Academic Article GET IT
Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Developmental neuroscience. 2005 Academic Article GET IT
Times cited: 17
L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons. Brain research. Molecular brain research. 2004 Academic Article GET IT
Times cited: 9
L-type Ca2+ channels mediate adaptation of extracellular signal-regulated kinase 1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 52
Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. Journal of neurochemistry. 2003 Academic Article GET IT
Times cited: 141
Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain research. 2001 Academic Article GET IT
Times cited: 31
Intracellular modulation of NMDA receptor function by antipsychotic drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 140
L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Academic Article GET IT
Times cited: 150
Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization. Cytogenetics and cell genetics. 1998 Academic Article GET IT
Times cited: 7
Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Developmental neuroscience. 1998 Academic Article GET IT
Times cited: 30
NF-IL6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 91
Location of nucleosomes in simian virus 40 chromatin. Journal of molecular biology. 1990 Academic Article GET IT
Times cited: 44
Locations of nucleosomes on the regulatory region of simian virus 40 chromatin. Journal of molecular biology. 1989 Academic Article GET IT
Times cited: 47

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Research

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Co-investigator Network

Funding awarded

Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid Crosstalk awarded by National Institute on Drug Abuse Principal Investigator 2022 - 2027
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memories awarded by National Institute on Drug Abuse Principal Investigator 2022 - 2027
Addgene 695360 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Molecular and circuit defects underlying different SCN2A mutations and ASDs awarded by National Institute of Mental Health Co-Investigator 2019 - 2024

GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum Disorders awarded by National Institute of Mental Health Key Personnel 2020 - 2025
A reciprocal relationship between alcohol and the p450 enzyme aromatase awarded by National Institute on Alcohol Abuse & Alcoholism Key Personnel 2021 - 2024
The role of DNA methylation in gene regulation in a cocaine addiction model awarded by National Science Foundation Key Personnel 2021 - 2024

L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use And Mood Disorders awarded by Gary and Mary West Health Institute Principal Investigator Subaward 2020 - 2025

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Background

education and training

Ph.D., Purdue University 1992
B.S., University of Bombay (India) 1986

Contact

full name

Anjali M Rajadhyaksha

primary email

amr2011@med.cornell.edu

VIVO Weill Cornell Medical College

Anjali M Rajadhyaksha Professor of Neuroscience in Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email