Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection. Academic Article uri icon

Overview

abstract

  • To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.

publication date

  • September 1, 1998

Research

keywords

  • Ectromelia virus
  • Nitric Oxide Synthase

Identity

PubMed Central ID

  • PMC110049

Scopus Document Identifier

  • 0031818013

Digital Object Identifier (DOI)

  • 10.1128/JVI.72.9.7703-7706.1998

PubMed ID

  • 9696880

Additional Document Info

volume

  • 72

issue

  • 9