Insights from mathematical modeling of renal tubular function. Review uri icon

Overview

abstract

  • Mathematical models of proximal tubule have been developed which represent the important solute species within the constraints of known cytosolic concentrations, transport fluxes, and overall epithelial permeabilities. In general, model simulations have been used to assess the quantitative feasibility of what appear to be qualitatively plausible mechanisms, or alternatively, to identify incomplete rationalization of experimental observations. The examples considered include: (1) proximal water reabsorption, for which the lateral interspace is a locus for solute-solvent coupling; (2) ammonia secretion, for which the issue is prioritizing driving forces - transport on the Na+/H+ exchanger, on the Na,K-ATPase, or ammoniagenesis; (3) formate-stimulated NaCl reabsorption, for which simple addition of a luminal membrane chloride/formate exchanger fails to represent experimental observation, and (4) balancing luminal entry and peritubular exit, in which ATP-dependent peritubular K+ channels have been implicated, but appear unable to account for the bulk of proximal tubule cell volume homeostasis.

publication date

  • January 1, 1998

Research

keywords

  • Kidney Tubules, Proximal
  • Models, Biological

Identity

Scopus Document Identifier

  • 0031657107

Digital Object Identifier (DOI)

  • 10.1159/000020556

PubMed ID

  • 9730663

Additional Document Info

volume

  • 6

issue

  • 5