The antibody catalysis route to the total synthesis of epothilones. Academic Article uri icon

Overview

abstract

  • An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using antibody-catalyzed aldol and retro-aldol reactions. These precursors were then converted to epothilones A (1) and C (3) to complete the total synthesis.

publication date

  • December 8, 1998

Research

keywords

  • Antibodies, Catalytic
  • Epothilones
  • Epoxy Compounds
  • Fructose-Bisphosphate Aldolase
  • Thiazoles

Identity

PubMed Central ID

  • PMC24496

Scopus Document Identifier

  • 0032426662

Digital Object Identifier (DOI)

  • 10.1073/pnas.95.25.14603

PubMed ID

  • 9843936

Additional Document Info

volume

  • 95

issue

  • 25