Oxidative stress, antioxidant defences and aging. Review uri icon

Overview

abstract

  • Apoptosis and aging share common mechanisms in oxidative stress and mitochondrial involvement. Treatment of cultured neuroblastoma cells with a radical initiator induced apoptosis; raise in hydrogen peroxide and release of cytochrome c from mitochondria preceded collapse of mitochondrial potential and cell death. In rat hepatocytes treated with adriamycin incubation with exogenous Coenzyme Q10 counteracted the drug-induced increase of hydrogen peroxide and the fall of the mitochondrial potential, thus demonstrating the quinone antioxidant effect. Complex I activity and its rotenone sensitivity decreased in brain cortex non-synaptic mitochondria from old rats; a 5 kb mitochondrial DNA deletion was found only in the old rats. A similar behavior was found in human platelets from old individuals. The postulated energy decline was confirmed by the inhibitor sensitivities of platelet aggregation and lactate production. The lack of the 5 kb deletion in platelets throws doubts on mitochondrial DNA lesions as the only causes of mitochondrial dysfunction in aging.

publication date

  • January 1, 1998

Research

keywords

  • Aging
  • Antioxidants
  • Oxidative Stress

Identity

Scopus Document Identifier

  • 0032434233

Digital Object Identifier (DOI)

  • 10.1002/biof.5520080305

PubMed ID

  • 9914819

Additional Document Info

volume

  • 8

issue

  • 3-4