Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing. Academic Article uri icon

Overview

abstract

  • During repetitive action potential firing the maintenance of synaptic transmission relies on a continued supply of synaptic vesicles for fusion with the presynaptic plasma membrane. The mechanism of transport by which vesicles are delivered to the site of fusion from a reserve pool is unknown, as are the biochemical pathways linking intracellular Ca2+ elevation with vesicle mobilization. Here, using the fluorescent tracer FM1-43 in hippocampal synaptic terminals, I show that inhibitors of myosin light chain kinase can block mobilization of the reserve pool and not the immediately releasable pool.

publication date

  • February 15, 1999

Research

keywords

  • Enzyme Inhibitors
  • Myosin-Light-Chain Kinase
  • Synaptic Vesicles

Identity

PubMed Central ID

  • PMC6786038

Scopus Document Identifier

  • 0033557648

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.19-04-01317.1999

PubMed ID

  • 9952409

Additional Document Info

volume

  • 19

issue

  • 4