Ryan, Timothy A.

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GABA_BR silencing of nerve terminals. eLife. 2023 Academic Article GET IT
Times cited: 1
Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals. Science advances. 2021 Academic Article GET IT
Times cited: 29
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 3
Local Sourcing of Secretory Proteins in Faraway Places. Trends in neurosciences. 2020 Comment GET IT
Molecular Tuning of the Axonal Mitochondrial Ca²⁺ Uniporter Ensures Metabolic Flexibility of Neurotransmission. Neuron. 2019 Academic Article GET IT
Times cited: 73
Editorial overview: Molecular neuroscience. Current opinion in neurobiology. 2019 Editorial Article GET IT
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Academic Article GET IT
Times cited: 253
The control of release probability at nerve terminals. Nature reviews. Neuroscience. 2019 Review GET IT
Times cited: 47
Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca_V2.1 and Ca_V2.2 in Rat Midbrain Neurons. eNeuro. 2019 Academic Article GET IT
Times cited: 9
A Path(way) to Keeping Your Synapses on an Even Keel. Neuron. 2018 Comment GET IT
Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation. Toxicology and applied pharmacology. 2018 Academic Article GET IT
Times cited: 32
Munc13 marks the spot. Nature neuroscience. 2018 Comment GET IT
Times cited: 1
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. The Journal of cell biology. 2017 Academic Article GET IT
Times cited: 170
Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Academic Article GET IT
Times cited: 77
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017 Academic Article GET IT
Times cited: 186
Glucose metabolism in nerve terminals. Current opinion in neurobiology. 2017 Review GET IT
Times cited: 80
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017 Academic Article GET IT
Times cited: 100
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 62
Axonal Endoplasmic Reticulum Ca²⁺ Content Controls Release Probability in CNS Nerve Terminals. Neuron. 2017 Academic Article GET IT
Times cited: 152
Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons. Scientific reports. 2017 Academic Article GET IT
Times cited: 11
GLUT4 Mobilization Supports Energetic Demands of Active Synapses. Neuron. 2017 Academic Article GET IT
Times cited: 158
The Global Challenge in Neuroscience Education and Training: The MBL Perspective. Neuron. 2016 Academic Article GET IT
Times cited: 4
Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 16
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 60
Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 32
The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels. eLife. 2015 Academic Article GET IT
Times cited: 41
Synaptic activity regulates the abundance and binding of complexin. Biophysical journal. 2015 Academic Article GET IT
Times cited: 7
Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals. Neuron. 2014 Academic Article GET IT
Times cited: 68
Activity-driven local ATP synthesis is required for synaptic function. Cell. 2014 Academic Article GET IT
Times cited: 448
Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts. eLife. 2013 Academic Article GET IT
Times cited: 55
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 36
Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 65
Intrinsic variability in Pv, RRP size, Ca(2+) channel repertoire, and presynaptic potentiation in individual synaptic boutons. Frontiers in synaptic neuroscience. 2013 Academic Article GET IT
Times cited: 31
Calbindin controls release probability in ventral tegmental area dopamine neurons. Nature neuroscience. 2012 Academic Article GET IT
Times cited: 41
α2δ expression sets presynaptic calcium channel abundance and release probability. Nature. 2012 Academic Article GET IT
Times cited: 267
New insights into molecular players involved in neurotransmitter release. Physiology (Bethesda, Md.). 2012 Review GET IT
Times cited: 14
A system for performing high throughput assays of synaptic function. PloS one. 2011 Academic Article GET IT
Times cited: 24
Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Neuron. 2011 Academic Article GET IT
Times cited: 152
Synaptic vesicle retrieval time is a cell-wide rather than individual-synapse property. Nature neuroscience. 2011 Academic Article GET IT
Times cited: 22
CDK5 serves as a major control point in neurotransmitter release. Neuron. 2010 Academic Article GET IT
Times cited: 210
Optical mapping of release properties in synapses. Frontiers in neural circuits. 2010 Academic Article GET IT
Times cited: 39
Neuronal protein economics: keeping tabs on synthesis. Nature neuroscience. 2010 Comment GET IT
A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 18
Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons. Frontiers in neural circuits. 2009 Academic Article GET IT
Times cited: 27
Synaptic vesicle recycling at CNS snapses without AP-2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 101
Molecular circuitry of endocytosis at nerve terminals. Annual review of cell and developmental biology. 2009 Review GET IT
Times cited: 187
A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses. Brain cell biology. 2008 Academic Article GET IT
Times cited: 65
Calcium control of endocytic capacity at a CNS synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 74
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals. Neuron. 2007 Academic Article GET IT
Times cited: 146
Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 214
Modes of vesicle retrieval at ribbon synapses, calyx-type synapses, and small central synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Review GET IT
Times cited: 85
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 412
Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling. Neuron. 2006 Academic Article GET IT
Times cited: 159
The efficiency of the synaptic vesicle cycle at central nervous system synapses. Trends in cell biology. 2006 Review GET IT
Times cited: 58
A pre-synaptic to-do list for coupling exocytosis to endocytosis. Current opinion in cell biology. 2006 Review GET IT
Times cited: 43
The synaptic vesicle: cycle of exocytosis and endocytosis. Current opinion in neurobiology. 2006 Review GET IT
Times cited: 109
The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Times cited: 125
Neural activity controls the synaptic accumulation of alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 217
The general anesthetic isoflurane depresses synaptic vesicle exocytosis. Molecular pharmacology. 2005 Academic Article GET IT
Times cited: 52
Highly cooperative control of endocytosis by clathrin. Molecular biology of the cell. 2005 Academic Article GET IT
Times cited: 39
Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons. Neuropharmacology. 2005 Academic Article GET IT
Times cited: 17
Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 108
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature. 2004 Academic Article GET IT
Times cited: 308
Syntaxin-1A is excluded from recycling synaptic vesicles at nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 43
The kinetics of synaptic vesicle pool depletion at CNS synaptic terminals. Neuron. 2004 Academic Article GET IT
Times cited: 184
Fluorescent proteins with ties that bind. Nature biotechnology. 2003 Comment GET IT
Times cited: 1
Targeted chemical disruption of clathrin function in living cells. Molecular biology of the cell. 2003 Academic Article GET IT
Times cited: 53
Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron. 2003 Academic Article GET IT
Times cited: 270
Kiss-and-run, fuse-pinch-and-linger, fuse-and-collapse: the life and times of a neurosecretory granule. Proceedings of the National Academy of Sciences of the United States of America. 2003 Comment GET IT
Times cited: 62
Actin has a molecular scaffolding, not propulsive, role in presynaptic function. Nature neuroscience. 2003 Academic Article GET IT
Times cited: 257
Regulation of neurotransmitter release by synapsin III. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Academic Article GET IT
Times cited: 126
Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. The Journal of physiology. 2002 Academic Article GET IT
Times cited: 94
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron. 2002 Academic Article GET IT
Times cited: 193
NCAM and vesicle cycling: the importance of good glue in the long run. Neuron. 2001 Comment GET IT
Times cited: 7
Synapsin dispersion and reclustering during synaptic activity. Nature neuroscience. 2001 Academic Article GET IT
Times cited: 293
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 181
Presynaptic imaging techniques. Current opinion in neurobiology. 2001 Review GET IT
Times cited: 80
Calcium accelerates endocytosis of vSNAREs at hippocampal synapses. Nature neuroscience. 2001 Academic Article GET IT
Times cited: 251
Measurements of vesicle recycling in central neurons. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. 2001 Review GET IT
Times cited: 13
The use of pHluorins for optical measurements of presynaptic activity. Biophysical journal. 2000 Academic Article GET IT
Times cited: 433
Real-time measurements of vesicle-SNARE recycling in synapses of the central nervous system. Nature cell biology. 2000 Academic Article GET IT
Times cited: 345
Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Academic Article GET IT
Times cited: 135
Probing a complex question: when are SNARE proteins ensnared?. Nature neuroscience. 1998 Comment GET IT
Times cited: 5
Optical detection of a quantal presynaptic membrane turnover. Nature. 1997 Academic Article GET IT
Times cited: 142
Endocytosis at nerve terminals: timing is everything. Neuron. 1996 Review GET IT
Times cited: 23
Synaptic vesicle recycling in synapsin I knock-out mice. The Journal of cell biology. 1996 Academic Article GET IT
Times cited: 145
Potentiation of evoked vesicle turnover at individually resolved synaptic boutons. Neuron. 1996 Academic Article GET IT
Times cited: 97
The timing of synaptic vesicle endocytosis. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 204
Vesicle pool mobilization during action potential firing at hippocampal synapses. Neuron. 1995 Academic Article GET IT
Times cited: 248
The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron. 1993 Academic Article GET IT
Times cited: 466
Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 131
Imaging [Ca2+]i dynamics during signal transduction. Cell calcium. 1990 Academic Article GET IT
Times cited: 22
Immunoglobulin E receptor cross-linking induces oscillations in intracellular free ionized calcium in individual tumor mast cells. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 98
Molecular Interactions on the Cell Surface Revealed by Electrophoresis. The Biological bulletin. 1989 Academic Article GET IT
Calcium: an important second messenger in mast cells. Ciba Foundation symposium. 1989 Review GET IT
Times cited: 17
Molecular crowding on the cell surface. Science (New York, N.Y.). 1988 Academic Article GET IT
Times cited: 125

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Research

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Funding awarded

Metabolic Vulnerability of Synapses in Neurodegenerative Disease awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2020 - 2025
Physiology of single synaptic CNS terminals awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2020 - 2024
Addgene 700216 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Synaptic Mechanisms of General Anesthetic Action awarded by National Institute of General Medical Sciences Co-Investigator 2020 - 2024

Impaired integration of organelle function in Parkinson''s disease awarded by Gary and Mary West Health Institute Principal Investigator Subaward 2020 - 2023

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Background

education and training

Ph.D., Cornell University 1989
M.S., Cornell University 1986
M.Sc., McGill University (Canada) 1983
B.Sc., McGill University (Canada) 1981

Contact

full name

Timothy A. Ryan

primary email

taryan@med.cornell.edu

VIVO Weill Cornell Medical College

Timothy A. Ryan Professor

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email